Oncological resection, myasthenia gravis and staging as prognostic factors in thymic tumours: a Chilean case series

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dc.article.number1201
dc.catalogadorpva
dc.contributor.authorSalas, Patricio
dc.contributor.authorSolovera, Maria Eliana
dc.contributor.authorBannura, Felipe
dc.contributor.authorMuñoz-Medel, Matias
dc.contributor.authorCordova-Delgado, Miguel
dc.contributor.authorSanchez, Cesar
dc.contributor.authorIbañez, Carolina
dc.contributor.authorGarrido, Marcelo
dc.contributor.authorKoch, Erica
dc.contributor.authorAcevedo, Francisco
dc.contributor.authorMondaca, Sebastian
dc.contributor.authorNervi, Bruno
dc.contributor.authorMadrid, Jorge
dc.contributor.authorPeña, Jose
dc.contributor.authorPinto, Mauricio P.
dc.contributor.authorValbuena, José
dc.contributor.authorGalindo, Hector
dc.date.accessioned2024-01-19T18:21:49Z
dc.date.available2024-01-19T18:21:49Z
dc.date.issued2021
dc.description.abstractBackground: Thymic epithelial tumours are rare and highly heterogeneous. Reports from the United States suggest an overall incidence of 0.15 per 100,000/year. In contrast, the incidence of these tumours in Latin America is largely unknown and reports are scarce, somewhat limited to case reports. Methods: Herein, we report a series of 38 thymic tumours from a single institution, retrospectively incorporated into this study. Patient characteristics and outcomes including age, sex, stage, paraneoplastic syndromes, treatment regimens and the date of decease were obtained from medical records. Results: Most cases in our series were females and young age (<50 years old) and early stage by Masaoka-Koga or the Moran staging systems. Also, a 34% of patients had myasthenia gravis (MG). Next, we analysed overall survival rates in our series and found that the quality of surgery (R0, R1 or R2), MG status and staging (Masaoka-Koga, Moran or TNM) were prognostic factors. Finally, we compared our data to larger thymic tumour series. Conclusions: Overall, our study confirms complete surgical resection as the standard, most effective treatment for thymic epithelial tumours. Also, the Masaoka-Koga staging system remains as a reliable prognostic factor but also the Moran staging system should be considered for thymomas.
dc.fechaingreso.objetodigital2024-06-04
dc.fuente.origenORCID-ene24
dc.identifier.doi10.3332/ecancer.2021.1201
dc.identifier.urihttp://dx.doi.org/10.3332/ecancer.2021.1201
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80804
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolas; 0000-0003-3482-7746; 119540
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final8
dc.pagina.inicio1
dc.revistaecancer
dc.rightsacceso abierto
dc.rights.licenseCC BY 3.0 DEED Attribution 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subjectThymic tumour
dc.subjectThymoma
dc.subjectMyasthenia gravis
dc.subjectStaging
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleOncological resection, myasthenia gravis and staging as prognostic factors in thymic tumours: a Chilean case series
dc.typeartículo
dc.volumen15
sipa.codpersvinculados119540
sipa.trazabilidadORCID;2024-01-08
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