Evidences for mineralocorticoid excess in essential hypertension

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dc.contributor.authorCortes, P
dc.contributor.authorFardella, C
dc.contributor.authorOestreicher, E
dc.contributor.authorGac, H
dc.contributor.authorMosso, L
dc.contributor.authorSoto, J
dc.contributor.authorForadori, A
dc.contributor.authorClaverie, X
dc.contributor.authorAhuad, J
dc.contributor.authorMontero, J
dc.date.accessioned2024-08-15T08:00:04Z
dc.date.available2024-08-15T08:00:04Z
dc.date.issued2000
dc.description.abstractBackground: Primary hyperaldosteronism is more frequent among subjects with essential hypertension than previously thought. The prevalence, according to local and international evidence could fluctuate between 9 and 10%. Aim: To investigate if subjects with essential hypertension have different aldosterone and renin plasma levels than normotensive subjects. Patients and methods: One hundred twenty five subjects with essential hypertension, not receiving medications for a least two weeks prior to the study and 168 age and sex matched normotensive controls were studied. Blood was drawn between 9 and 10 AM during a sodium free diet to determine plasma aldosterone, plasma renin activity and potassium. Results: Plasma aldosterone was higher in hypertensive subjects than controls (11.6 +/- 7.6 and 9.9 +/- 5.1 ng/dl respectively; p = 0.04). Plasma renin activity was lower in hypertensives than controls (1.42 +/- 1.28 and 1.88 +/- 1.39 ng/ml/h respectively; p < 0.001). Thus, plasma aldosterone/plasma renin activity ratio was higher in hypertensives (13.8 +/- 13.5 and 8.3 +/- 7.8; p < 0.001), A pathological ratio was defined as over 25, corresponding to the mean plus two standard deviations of the control group. Primary hyperaldosteronism was found in 5/125 hypertensives (4%) and 1/168 normotensive subject (0.6%). None had hypokalemia. Conclusions: Subjects with essential hypertension have higher plasma aldosterone and lower plasma renin activity than normal controls. A plasma aldosterone/plasma renin activity over 25 was defined as abnormal.
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:11349499
dc.identifier.scopusidSCOPUS_ID:0033155140
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87436
dc.identifier.wosidWOS:000165243600001
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero9
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final961
dc.pagina.inicio955
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectaldosterone
dc.subjecthyperaldosteronism
dc.subjecthypertension
dc.subjectSEVERE 17-ALPHA-HYDROXYLASE DEFICIENCY
dc.subjectLOW-RENIN HYPERTENSION
dc.subjectPRIMARY HYPERALDOSTERONISM
dc.subjectPRIMARY ALDOSTERONISM
dc.subjectDIAGNOSIS
dc.subjectP450C11AS
dc.subjectMUTATION
dc.subjectGENE
dc.titleEvidences for mineralocorticoid excess in essential hypertension
dc.typeartículo
dc.volumen128
sipa.codpersvinculados88201
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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