Regiochemical control in the amination reaction of phenanthridine-7,10-quinones

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dc.contributor.authorValderrama, Jaime A.
dc.contributor.authorAndrea Ibacache, J.
dc.date.accessioned2024-01-10T12:42:00Z
dc.date.available2024-01-10T12:42:00Z
dc.date.issued2009
dc.description.abstractThe reaction of substituted phenanthridine-7,10-quinones with amines to construct novel aminophenanthridinequinone derivatives as antitumor agents is described. The regiochemistry of the amination reaction is discussed in terms of inductive and steric effects of remote substituents to the quinone ring, which Control the direction of the conjugate addition of the amines across the quinone double bond. Evidences on the significant in vitro antitumor activities of some of the obtained aminoquinones, are reported. (C) 2009 Elsevier Ltd. All rights Reserved.
dc.description.funderFONDECYT
dc.description.funderCONICYT
dc.fechaingreso.objetodigital11-04-2024
dc.format.extent3 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.tetlet.2009.05.042
dc.identifier.issn0040-4039
dc.identifier.urihttps://doi.org/10.1016/j.tetlet.2009.05.042
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77471
dc.identifier.wosidWOS:000267495900016
dc.information.autorucQuímica;Ibacache JA;S/I;165677
dc.information.autorucQuímica;Valderrama JA;S/I;98772
dc.issue.numero30
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final4363
dc.pagina.inicio4361
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaTETRAHEDRON LETTERS
dc.rightsacceso restringido
dc.subjectPhenanthridinequinones
dc.subjectSubstitution reaction
dc.subjectRegioselectivity
dc.subjectCytotoxicity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRegiochemical control in the amination reaction of phenanthridine-7,10-quinones
dc.typeartículo
dc.volumen50
sipa.codpersvinculados165677
sipa.codpersvinculados98772
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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