Dietary phenolic compounds as modulators of AGEs-induced photo-oxidation: A focus on the skin and eye lens

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dc.article.number100068
dc.catalogadorgjm
dc.contributor.authorÁvila, Felipe
dc.contributor.authorFuentealba Patiño, Denis Alberto
dc.contributor.authorMuñoz, Francisca
dc.contributor.authorSan Martin, Alejandra
dc.contributor.authorFriguet, Bertrand
dc.date.accessioned2026-01-07T18:51:38Z
dc.date.available2026-01-07T18:51:38Z
dc.date.issued2026
dc.description.abstractAdvanced glycation end products (AGEs) are irreversible products formed when long-lived proteins undergo non-enzymatic reactions with reducing sugars or reactive metabolites. These products resist proteolytic degradation and therefore accumulate with age. Some AGEs act as chromophores, absorbing UVA-visible light and initiating photosensitized oxidation, a process implicated in photoaging of tissues such as the eye lens and skin. Dietary polyphenols, known for their antioxidant and antiglycation effects, may also modulate AGE-mediated photosensitized reactions, although this remains poorly understood. This article discusses the mechanisms through which AGEs contribute to photo-oxidative damage in light-exposed tissues and discusses the potential of dietary polyphenols to modulate these photo-induced processes.
dc.fechaingreso.objetodigital2026-01-07
dc.format.extent11 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.rbc.2025.100068
dc.identifier.urihttps://doi.org/10.1016/j.rbc.2025.100068
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107579
dc.information.autorucEscuela de Química; Fuentealba Patiño, Denis Alberto; 0000-0003-4798-7204; 160255
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaRedox Biochemistry and Chemistry
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMaillard reaction
dc.subjectPhotosensitized reactions
dc.subjectProtein crosslinking
dc.subjectPhoto-aging
dc.subjectPolyphenols
dc.subject.ddc510
dc.titleDietary phenolic compounds as modulators of AGEs-induced photo-oxidation: A focus on the skin and eye lens
dc.typeartículo
dc.volumen15
sipa.codpersvinculados160255
sipa.trazabilidadORCID;2026-01-05
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