Soluble Interleukin-6 Receptor Regulates Interleukin-6-Dependent Vascular Remodeling in Long-Distance Runners

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dc.article.number722528
dc.catalogadorjca
dc.contributor.authorVillar Fincheira, Paulina
dc.contributor.authorParedes, Aaron J.
dc.contributor.authorHernandez Diaz, Tomas
dc.contributor.authorNorambuena Soto, Ignacio
dc.contributor.authorCancino Arenas, Nicole
dc.contributor.authorSanhueza Olivares, Fernanda
dc.contributor.authorContreras Briceño, Felipe
dc.contributor.authorMandiola Ovalle, Jorge
dc.contributor.authorBruneau, Nicole
dc.contributor.authorGarcia, Lorena
dc.contributor.authorOcaranza, María Paz
dc.contributor.authorTroncoso, Rodrigo
dc.contributor.authorGabrielli, Luigi
dc.contributor.authorChiong, Mario
dc.date.accessioned2024-01-23T15:57:02Z
dc.date.available2024-01-23T15:57:02Z
dc.date.issued2021
dc.description.abstractLittle is known about the effects of training load on exercise-induced plasma increase of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) and their relationship with vascular remodeling. We sought to evaluate the role of sIL 6R as a regulator of IL-6-induced vascular remodeling. Forty-four male marathon runners were recruited and allocated into two groups: low-training (LT, <100 km/week) and high-training (HT, >= 100 km/week), 22 athletes per group. Twenty-one sedentary participants were used as reference. IL-6, sIL-6R and sgp130 levels were measured in plasma samples obtained before and immediately after finishing a marathon (42.2-km). Aortic diameter was measured by echocardiography. The inhibitory effect of sIL-6R on IL-6-induced VSMC migration was assessed using cultured A7r5 VSMCs. Basal plasma IL-6 and sIL-6R levels were similar among sedentary and athlete groups. Plasma IL-6 and sIL-6R levels were elevated after the marathon, and HT athletes had higher post-race plasma sIL-6R, but not IL-6, level than LT athletes. No changes in sgp130 plasma levels were found in LT and HT groups before and after running the marathon. Athletes had a more dilated ascending aorta and aortic root than sedentary participants with no differences between HT and LT athletes. However, a positive correlation between ascending aorta diameter and plasma IL-6 levels corrected by training load and years of training was observed. IL-6 could be responsible for aorta dilation because IL-6 stimulated VSMC migration in vitro, an effect that is inhibited by sIL-6R. However, IL-6 did not modify cell proliferation, collagen type I and contractile protein of VSMC. Our results suggest that exercise induces vascular remodeling. A possible association with IL-6 is proposed. Because sIL-6R inhibits IL-6-induced VSMC migration, a possible mechanism to regulate IL-6-dependent VSMC migration is also proposed.
dc.description.funderFONDECYT
dc.description.funderFONDAP
dc.fechaingreso.objetodigital2024-01-23
dc.fuente.origenScopus
dc.identifier.doi10.3389/fphys.2021.722528
dc.identifier.eissn1664042X
dc.identifier.issn1664-042X
dc.identifier.pubmedidMEDLINE:34707507
dc.identifier.scopusidSCOPUS_ID:85117760625
dc.identifier.urihttps://doi.org/10.3389/fphys.2021.722528
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80918
dc.information.autorucEscuela de Medicina; Contreras Briceño, Felipe; 0000-0002-0674-7506; 1011730
dc.information.autorucEscuela de Medicina; Mandiola Ovalle, Jorge; S/I; 243293
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherFrontiers Media S.A.
dc.relation.ispartofFrontiers in Physiology
dc.revistaFrontiers in Physiology
dc.rightsacceso abierto
dc.subjectExercise
dc.subjectInterleukin-6
dc.subjectRunners
dc.subjectSoluble interleukin-6 receptor
dc.subjectVascular smooth muscle cell
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleSoluble Interleukin-6 Receptor Regulates Interleukin-6-Dependent Vascular Remodeling in Long-Distance Runners
dc.typeartículo
dc.volumen12
sipa.codpersvinculados1011730
sipa.codpersvinculados243293
sipa.trazabilidadSCOPUS;21-03-2022
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