Three-year incidence and acute setting predictors of epilepsy after neonatal and childhood arterial ischaemic stroke: a disease-based cohort study

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dc.catalogadorgrr
dc.contributor.authorLópez Espejo, Mauricio Alejandro
dc.contributor.authorSkorin Barriga, Ilona Stefania
dc.contributor.authorMesa Latorre, Manuel Tomás
dc.contributor.authorHernandez Chavez, Marta Isabel
dc.date.accessioned2024-01-11T18:08:55Z
dc.date.available2024-01-11T18:08:55Z
dc.date.issued2024
dc.description.abstractTo assess the association between clinical and MRI characteristics of arterial ischaemic stroke (AIS) and the 3-year risk of post-stroke epilepsy (PSE) in paediatric patients. Retrospective cohort study. Database from a single tertiary referral centre for paediatric stroke in Chile. Two hundred seven neonates and children (1 day to 18 years) with a first-ever supratentorial AIS diagnosed between January 2003 and December 2019 were evaluated. Diagnosis of PSE and explanatory variables were consecutively recorded from hospital inpatient and annual outpatient records in a predesigned database. Competing risk analysis (competing events: death and loss to follow-up) of multiple Cox proportional hazards regression was performed to estimate adjusted subhazard ratios (SHRs) of PSE. Confidence intervals (95% CI) were calculated using bootstrap resampling (1000 replications). Interaction terms were added to investigate moderating effects. The 3-year incidence rate of PSE was 166.5 per 1000 person-years (neonatal: 150.1; childhood: 173.9). The 3-year cumulative incidence was 33%. Patients with acute symptomatic non-status seizures (SHR = 3.13; 95% CI = 1.43–6.82), status epilepticus (SHR = 5.16; 95% CI = 1.90–13.96), abnormal discharge neurological status (SHR = 2.52; 95% CI = 1.12–5.63), cortical lesions (SHR = 2.93; 95% CI = 1.48–5.81), and multifocal infarcts with stroke size < 5% of supratentorial brain volume (SHR = 3.49; 95% CI = 1.44–8.46) had a higher risk of PSE.Conclusion: This study identified specific and reliable acute clinical and imaging predictors of PSE in paediatric patients, helping clinicians identify high-risk patients with potential implications for treatment decisions.
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1007/s00431-023-05384-4
dc.identifier.pubmedid38170290
dc.identifier.urihttps://doi.org/10.1007/s00431-023-05384-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80423
dc.information.autorucEscuela de Medicina; López Espejo, Mauricio Alejandro; 0000-0003-4278-9188; 209731
dc.information.autorucEscuela de Medicina; Skorin Barriga, Ilona Stefania; S/I; 142515
dc.information.autorucEscuela de Medicina; Mesa Latorre, Manuel Tomás; S/I; 54102
dc.information.autorucEscuela de Medicina; Hernandez Chavez, Marta Isabel; 0000-0992-4238-8969; 55673
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaEuropean Journal of Pediatrics
dc.rightsacceso restringido
dc.subjectEpilepsy
dc.subject Stroke 
dc.subjectChildren
dc.subjectCompeting risk 
dc.subjectChildren
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleThree-year incidence and acute setting predictors of epilepsy after neonatal and childhood arterial ischaemic stroke: a disease-based cohort study
dc.typeartículo
sipa.codpersvinculados209731
sipa.codpersvinculados142515
sipa.codpersvinculados54102
sipa.codpersvinculados55673
sipa.trazabilidadORCID;2024-01-15
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