Extracellular vesicles through the blood–brain barrier: a review

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dc.article.number60
dc.contributor.authorRamos Zaldívar, Héctor M.
dc.contributor.authorPolakovicova, Iva
dc.contributor.authorSalas-Huenuleo, Edison
dc.contributor.authorCorvalán R., Alejandro
dc.contributor.authorKogan, Marcelo J.
dc.contributor.authorYefi Rubio, Claudia Pamela
dc.contributor.authorAndía Kohnenkampf, Marcelo Edgardo
dc.date.accessioned2022-08-12T14:39:48Z
dc.date.available2022-08-12T14:39:48Z
dc.date.issued2022
dc.date.updated2022-07-31T00:03:47Z
dc.description.abstractExtracellular vesicles (EVs) are particles naturally released from cells that are delimited by a lipid bilayer and are unable to replicate. How the EVs cross the Blood–Brain barrier (BBB) in a bidirectional manner between the bloodstream and brain parenchyma remains poorly understood. Most in vitro models that have evaluated this event have relied on monolayer transwell or microfluidic organ-on-a-chip techniques that do not account for the combined effect of all cellular layers that constitute the BBB at different sites of the Central Nervous System. There has not been direct transcytosis visualization through the BBB in mammals in vivo, and evidence comes from in vivo experiments in zebrafish. Literature is scarce on this topic, and techniques describing the mechanisms of EVs motion through the BBB are inconsistent. This review will focus on in vitro and in vivo methodologies used to evaluate EVs transcytosis, how EVs overcome this fundamental structure, and discuss potential methodological approaches for future analyses to clarify these issues. Understanding how EVs cross the BBB will be essential for their future use as vehicles in pharmacology and therapeutics.
dc.format.extent15 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationFluids and Barriers of the CNS. 2022 Jul 25;19(1):60
dc.identifier.doi10.1186/s12987-022-00359-3
dc.identifier.urihttps://doi.org/10.1186/s12987-022-00359-3
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/64523
dc.identifier.wosidWOS:000829963500001
dc.information.autorucEscuela de medicina ; Ramos Zaldívar, Héctor M. ; S/I ; 1063947
dc.information.autorucEscuela de medicina ; Polakovicova, Iva ; S/I ; 1018034
dc.information.autorucEscuela de medicina ; Corvalán R., Alejandro ; 0000-0001-5492-3853 ; 63885
dc.information.autorucEscuela de medicina ; Yefi Rubio, Claudia Pamela ; 0000-0001-8697-7143 ; 1086119
dc.information.autorucEscuela de medicina ; Andía Kohnenkampf, Marcelo Edgardo ; 0000-0002-1251-5832 ; 90691
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final15
dc.pagina.inicio1
dc.revistaFluids and Barriers of the CNSes_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectExtracellular vesicleses_ES
dc.subjectBlood–Brain barrieres_ES
dc.subjectTranscytosises_ES
dc.subjectExosomeses_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExtracellular vesicles through the blood–brain barrier: a reviewes_ES
dc.typeartículo
dc.volumen19
sipa.codpersvinculados1063947
sipa.codpersvinculados1018034
sipa.codpersvinculados63885
sipa.codpersvinculados1086119
sipa.codpersvinculados90691
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