High-resolution non-contrast free-breathing coronary cardiovascular magnetic resonance angiography for detection of coronary artery disease : validation against invasive coronary angiography

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dc.contributor.authorNazir, Muhummad S.
dc.contributor.authorBustin, Aurélien
dc.contributor.authorHajhosseiny, Reza
dc.contributor.authorYazdani, Momina
dc.contributor.authorRyan, Matthew
dc.contributor.authorVergani, Vittoria
dc.contributor.authorNeji, Radhouene
dc.contributor.authorKunze, Karl P.
dc.contributor.authorPerera, Divaka
dc.contributor.authorBotnar, René Michael
dc.contributor.authorPrieto Vásquez, Claudia
dc.date.accessioned2022-05-09T19:44:06Z
dc.date.available2022-05-09T19:44:06Z
dc.date.issued2022
dc.date.updated2022-04-17T00:03:19Z
dc.description.abstractCoronary artery disease (CAD) is the single most common cause of death worldwide. Recent technological developments with coronary cardiovascular magnetic resonance angiography (CCMRA) allow high-resolution free-breathing imaging of the coronary arteries at submillimeter resolution without contrast in a predictable scan time of ~ 10 min. The objective of this study was to determine the diagnostic accuracy of high-resolution CCMRA for CAD detection against the gold standard of invasive coronary angiography (ICA). Methods: Forty-five patients (15 female, 62 ± 10 years) with suspected CAD underwent sub-millimeter-resolution (0.6 mm3) non-contrast CCMRA at 1.5T in this prospective clinical study from 2019–2020. Prior to CCMR, patients were given an intravenous beta blockers to optimize heart rate control and sublingual glyceryl trinitrate to promote coronary vasodilation. Obstructive CAD was defined by lesions with ≥ 50% stenosis by quantitative coronary angiography on ICA. Results: The mean duration of image acquisition was 10.4 ± 2.1 min. On a per patient analysis, the sensitivity, specificity, positive predictive value and negative predictive value (95% confidence intervals) were 95% (75–100), 54% (36–71), 60% (42–75) and 93% (70–100), respectively. On a per vessel analysis the sensitivity, specificity, positive predictive value and negative predictive value (95% confidence intervals) were 80% (63–91), 83% (77–88), 49% (36–63) and 95% (90–98), respectively. Conclusion: As an important step towards clinical translation, we demonstrated a good diagnostic accuracy for CAD detection using high-resolution CCMRA, with high sensitivity and negative predictive value. The positive predictive value is moderate, and combination with CMR stress perfusion may improve the diagnostic accuracy. Future multicenter evaluation is now required
dc.format.extent26 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationJournal of Cardiovascular Magnetic Resonance. 2022 Apr 11;24(1):26
dc.identifier.urihttps://doi.org/10.1186/s12968-022-00858-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/63733
dc.information.autorucEscuela de Ingeniería ; Botnar, René Michael ; 0000-0003-2811-2509 ; 1015313
dc.information.autorucEscuela de Ingeniería ; Prieto Vásquez, Claudia ; S/I ; 14195
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.relation.isformatofJournal of Cardiovascular Magnetic Resonance, 24:1 (2022)
dc.revistaJournal of Cardiovascular Magnetic Resonance
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectCoronary imaginges_ES
dc.subjectCardiovascular magnetic resonance angiographyes_ES
dc.subjectCoronary artery diseasees_ES
dc.subject.ddc612
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.subject.otherImagen por resonancia magnéticaes_ES
dc.subject.otherEnfermedad de la arteria coronariaes_ES
dc.subject.otherAngiografía coronaria - Técnicaes_ES
dc.titleHigh-resolution non-contrast free-breathing coronary cardiovascular magnetic resonance angiography for detection of coronary artery disease : validation against invasive coronary angiographyes_ES
dc.typeartículo
dc.volumen24
sipa.codpersvinculados1015313
sipa.codpersvinculados14195
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