Development of mushroom polysaccharide and probiotics based solid self-nanoemulsifying drug delivery system loaded with curcumin and quercetin to improve their dissolution rate and permeability: State of the art

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dc.catalogadoryvc
dc.contributor.authorKhursheed, Rubiya
dc.contributor.authorSingh, Sachin Kumar
dc.contributor.authorWadhwa, Sheetu
dc.contributor.authorGulati, Monica
dc.contributor.authorKapoor, Bhupinder
dc.contributor.authorJain, Subheet Kumar
dc.contributor.authorGowthamarajan, Kuppusamy
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorChellappan, Dinesh Kumar
dc.contributor.authorGupta, Gaurav
dc.contributor.authorJha, Niraj Kumar
dc.contributor.authorGupta, Piyush Kumar
dc.contributor.authorDua, Kamal
dc.date.accessioned2023-08-24T21:45:12Z
dc.date.available2023-08-24T21:45:12Z
dc.date.issued2021
dc.description.abstractThe role of mushroom polysaccharides and probiotics as pharmaceutical excipients for development of nano-carriers has never been explored. In the present study an attempt has been made to explore Ganoderma lucidum extract powder (GLEP) containing polysaccharides and probiotics to convert liquid self nanoemulsifying drug delivery system (SNEDDS) into solid free flowing powder. Two lipophilic drugs, curcumin and quercetin were used in this study due to their dissolution rate limited oral bioavailability and poor permeability. These were loaded into liquid SNEDDS by dissolving them into isotropic mixture of Labrafill M1944CS, Capmul MCM, Tween-80 and Transcutol P. The liquid SNEDDS were solidified using probiotics and mushroom polysaccharides as carriers and Aerosil-200 as coating agent. The solidification was carried out using spray drying process. The process and formulation variables for spray drying process of liquid SNEDDS were optimized using Box Behnken Design to attain required powder properties. The release of both drugs from the optimized spray dried (SD) formulation was found to be more than 90%, whereas, it was less than 20% for unprocessed drugs. The results of DSC, PXRD and SEM, showed that the developed L-SNEDDS preconcentrate was successfully loaded onto the porous surface of probiotics, mushroom polysaccharides and Aerosil-200.
dc.description.funderDepartment of Science and Technology-fund for improvement of science and technology infrastructure in Universities and Higher Educational Institutions (DST-FIST), New Delhi
dc.fechaingreso.objetodigital2023-08-24
dc.format.extent14
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ijbiomac.2021.08.170
dc.identifier.eissn1879-0003
dc.identifier.issn0141-8130
dc.identifier.pubmedidMEDLINE_ID:34464640
dc.identifier.scopusidSCOPUS_ID:85113920494
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2021.08.170
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74493
dc.identifier.wosidWOS:000704333700008
dc.information.autorucEscuela de Química ; Zacconi, Flavia C. M. ; 0000-0002-3676-0453 ; 1011127
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final757
dc.pagina.inicio744
dc.publisherELSEVIER
dc.revistaINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
dc.rightsacceso restringido
dc.subjectMushroom polysaccharides
dc.subjectProbiotic
dc.subjectSpray drying
dc.subjectPRE/POST-COMPRESSION PROPERTIES
dc.subjectCACO-2 CELL-LINE
dc.subjectIN-VITRO
dc.subjectORAL BIOAVAILABILITY
dc.subjectFORMULATION DEVELOPMENT
dc.subjectDIABETES-MELLITUS
dc.subjectPOROUS CARRIERS
dc.subjectTOP-DOWN
dc.subjectOPTIMIZATION
dc.subjectIMPACT
dc.subject.ddc600
dc.subject.deweyTecnologíaes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDevelopment of mushroom polysaccharide and probiotics based solid self-nanoemulsifying drug delivery system loaded with curcumin and quercetin to improve their dissolution rate and permeability: State of the art
dc.typeartículo
dc.volumen189
sipa.codpersvinculados1011127
sipa.indexWoS
sipa.trazabilidadWOS;18-03-2022
sipa.trazabilidadScopus;12-10-2021
sipa.trazabilidadORCID; 2023-08-20
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