Stroke Patterns in Neonatal Group B Streptococcal Meningitis

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dc.contributor.authorHernandez, Marta I.
dc.contributor.authorSandoval, Carmen C.
dc.contributor.authorTapia, Jose L.
dc.contributor.authorMesa, Tomas
dc.contributor.authorEscobar, Raul
dc.contributor.authorHuete, Isidro
dc.contributor.authorWei, Xing Chang
dc.contributor.authorKirton, Adam
dc.date.accessioned2024-01-10T12:08:52Z
dc.date.available2024-01-10T12:08:52Z
dc.date.issued2011
dc.description.abstractNeonatal group B streptococcus meningitis causes neurologic morbidity and mortality. Cerebrovascular involvement is a common, poorly studied, and potentially modifiable pathologic process. We hypothesized that imaging patterns of focal brain infarction are recognizable in neonatal group B streptococcal meningitis. A consecutive case series included term neonates with the following: (1) bacterial meningitis, (2) acute group B streptococcal infection (positive cerebrospinal fluid/blood culture), (3) brain magnetic resonance imaging within 14 days, and (4) acute intraparenchymal focal infarctions (restricted diffusion). Lesions within known arterial territories were classified as arterial ischemic stroke. Clinical presentations, investigations, and neurologic outcomes were recorded. Eight newborns (50% female) with focal infarction were identified. Five presented early (<1 week), and all manifested clinical shock and elevated acute-phase reactants. Less than 50% had prenatal group B streptococcal screening, while 2 of 3 screened were negative. Two distinct patterns of focal infarction were identified: (1) deep perforator arterial stroke to basal ganglia, thalamus, and peri ventricular white matter (7/8, 88%), and (2) superficial injury with patchy, focal infarctions of the cortical surface (6/8, 75%). Outcomes (mean 23.8 months) were poor, with severe disability or death in 6/8 (75%). Recognizable stroke patterns contribute to severe neurologic outcomes and represent a potentially modifiable pathophysiologic process in neonatal group B streptococcal meningitis. (C) 2011 Elsevier Inc. All rights reserved.
dc.fechaingreso.objetodigital05-04-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.pediatrneurol.2010.11.002
dc.identifier.eissn1873-5150
dc.identifier.issn0887-8994
dc.identifier.pubmedidMEDLINE:21397170
dc.identifier.urihttps://doi.org/10.1016/j.pediatrneurol.2010.11.002
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76436
dc.identifier.wosidWOS:000288776400007
dc.information.autorucMedicina;Escobar R ;S/I;63818
dc.information.autorucMedicina;Hernandez M ;S/I;55673
dc.information.autorucMedicina;Mesa M;S/I;99641
dc.information.autorucMedicina;Sandoval C;S/I;116728
dc.issue.numero4
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final288
dc.pagina.inicio282
dc.publisherELSEVIER SCIENCE INC
dc.revistaPEDIATRIC NEUROLOGY
dc.rightsacceso restringido
dc.subjectARTERIAL ISCHEMIC-STROKE
dc.subjectSINOVENOUS THROMBOSIS
dc.subjectCEREBRAL INFARCTION
dc.subjectCHILDREN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStroke Patterns in Neonatal Group B Streptococcal Meningitis
dc.typeartículo
dc.volumen44
sipa.codpersvinculados63818
sipa.codpersvinculados55673
sipa.codpersvinculados99641
sipa.codpersvinculados116728
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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