Association between obesity and atopic dermatitis in children: A case-control study in a high obesity prevalence population

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dc.catalogadorjca
dc.contributor.authorIturriaga, Carolina
dc.contributor.authorBustos, María Francisca
dc.contributor.authorLe Roy, Catalina
dc.contributor.authorRodríguez, Rocío
dc.contributor.authorCifuentes, Lorena
dc.contributor.authorSilva-Valenzuela, Sergio
dc.contributor.authorVera-Kellet, Cristián
dc.contributor.authorCristi, Francisca
dc.contributor.authorPérez-Mateluna, Guillermo
dc.contributor.authorCabalín, Carolina
dc.contributor.authorHoyos-Bachiloglu, Rodrigo
dc.contributor.authorCamargo Jr., Carlos A.
dc.contributor.authorBorzutzky Schachter, Arturo
dc.date.accessioned2023-01-19T19:34:13Z
dc.date.available2023-01-19T19:34:13Z
dc.date.issued2022
dc.description.abstractBackground/Objective: Atopic dermatitis (AD) is a chronic inflammatory skin disease. Research suggests an association between obesity and AD, although evidence is lacking from Latin American populations. This study evaluated the association of obesity with AD in children from Chile, a country with high obesity prevalence. Methods: A case-control study was performed in children with active AD (cases) and healthy controls (HCs) from Santiago, Chile. Body mass index was evaluated by z-score (z-BMI), with overweight defined as z-BMI ≥+1 and <+2, and obesity as z-BMI ≥+2. Abdominal obesity was defined by a waist circumference-to-height ratio (WHR) ≥0.5. AD severity was evaluated by Scoring AD (SCORAD) index. Results: A total of 174 children with AD and 101 controls were included. AD patients had similar overweight (27% vs. 28%) and obesity (21% vs. 26%) rates as HCs (p = .65). Abdominal obesity rates were also comparable (64% vs. 62%, p = .81). In sex-specific analyses, girls with AD had higher abdominal obesity rates than HCs (71% vs. 53%, p < .05) while boys with AD had lower abdominal obesity rates than HCs (53% vs. 75%, p = .03). Among children with AD, higher z-BMI or WHR did not correlate with higher SCORAD, eosinophil counts or total IgE. Conclusion: In our study, Chilean children with AD had high but similar rates of obesity as HCs, but showed sex-specific associations of abdominal obesity and AD. Further research is needed to evaluate these associations and the roles that weight excess and weight loss could play in the pathogenesis and treatment of AD.
dc.description.funderAgencia Nacional de Investigacion y Desarrollo/Fondo Nacional de Desarrollo Cientifico y Tecnologico
dc.fechaingreso.objetodigital2023-01-19
dc.fuente.origenSIPA
dc.identifier.doi10.1111/pde.15110
dc.identifier.eissn1525-1470
dc.identifier.issn0736-8046
dc.identifier.urihttp://doi.org/10.1111/pde.15110
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/66391
dc.identifier.wosidWOS:000849754600001
dc.information.autorucFacultad de medicina ; Borzutzky Schachter, Arturo ; 0000-0002-7904-262X ; 5897
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final5
dc.pagina.inicio1
dc.revistaPediatric Dermatology
dc.rightsacceso abierto
dc.subjectAbdominal obesity
dc.subjectAtopic dermatitis
dc.subjectBody mass index
dc.subjectObesity
dc.subjectOverweight
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation between obesity and atopic dermatitis in children: A case-control study in a high obesity prevalence population
dc.typeartículo
sipa.codpersvinculados5897
sipa.indexWOS
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