Determination of time in range associated with HbA1c <= 6.5% in Latin American pregnant women diagnosed with type 1 diabetes mellitus using an automated insulin delivery system

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dc.catalogadorjwg
dc.contributor.authorMedina, Ana Maria Gomez
dc.contributor.authorChavez, Maria Juliana Soto
dc.contributor.authorCarrillo, Diana Cristina Henao
dc.contributor.authorSanchez, Juan Camilo Salgado
dc.contributor.authorGonzalez, Javier Alberto Gomez
dc.contributor.authorGrassi Corrales, Bruno
dc.contributor.authorVelandia, Oscar Mauricio Munoz
dc.date.accessioned2024-05-30T15:28:14Z
dc.date.available2024-05-30T15:28:14Z
dc.date.issued2023
dc.description.abstractAims: To determine the correlation between %TIR and HbA1c in pregnant women with type 1 diabetes mellitus (DM1)., Methods: Diagnostic test study in a prospective cohort of pregnant patients with DM1 using automated insulin delivery system (AID) in Colombia and Chile., Results: Fifty-two patients were included [mean age 31.8 +/- 6.2 years, pregestational HbA1c 7.2% [interquartile range (IQR), 6.5-8.2]. During follow-up, we found a better metabolic control during the second (HbA1c 6.40%, IQR 5.9,7.1) and third trimesters (HbA1c 6.25%;IQR 5.9,6.8). A weak and negative correlation between %TIR and HbA1c was found for all the gestation (Spearman's rank correlation coefficient:-0.22, p:0.0329), and in the second (r:-0.13, p: 0.38) and third trimesters (r:-0.26, p = 0.08). %TIR had poor discriminating capacity for predicting HbA1c < 6% (area under the curve [AUC], 0.59; 95% confidence interval [CI],0.46-0.72) and for predicting HbA1c < 6.5% (AUC, 0.57;95% CI,0.44-0.70). The optimal cutoff points for %TIR were > 66.1% for predicting HbA1c < 6% (65% sensitivity, 62% specificity) and %TIR > 61.1% for HbA1c < 6.5% (59% sensitivity, 54% specificity)., Conclusion: The correlation between HbA1c and %TIR during pregnancy was weak. The optimal cutoff points for identifying patients with HbA1c < 6.0% and < 6.5% were %TIR > 66.1% and > 61.1%, respectively, with moderate sensitivity and specificity.
dc.fechaingreso.objetodigital2024-10-18
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.diabres.2023.110713
dc.identifier.eissn1872-8227
dc.identifier.issn0168-8227
dc.identifier.urihttps://doi.org/10.1016/j.diabres.2023.110713
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/85987
dc.identifier.wosidWOS:001001985400001
dc.information.autorucEscuela de Medicina; Grassi Corrales Bruno; 0000-0003-0095-9740; 132804
dc.language.isoen
dc.nota.accesoContenido parcial
dc.publisherELSEVIER IRELAND LTD
dc.revistaDIABETES RESEARCH AND CLINICAL PRACTICE
dc.rightsacceso restringido
dc.subjectTime in range
dc.subjectContinuous glucose monitoring
dc.subjectGlycated hemoglobin A1c
dc.subjectType 1 diabetes
dc.subjectPregnancy
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDetermination of time in range associated with HbA1c <= 6.5% in Latin American pregnant women diagnosed with type 1 diabetes mellitus using an automated insulin delivery system
dc.typeartículo
dc.volumen200
sipa.codpersvinculados132804
sipa.trazabilidadORCID;2024-05-27
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