Adiponectin in severe preeclampsia

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dc.catalogadorpau
dc.contributor.authorNien, J. K.
dc.contributor.authorMazaki-Tovi, S.
dc.contributor.authorRomero, R.
dc.contributor.authorErez, O.
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorGotsch, F.
dc.contributor.authorPineles, B. L.
dc.contributor.authorGómez Mora, Ricardo Alberto
dc.contributor.authorEdwin, S.
dc.contributor.authorMazor, M.
dc.contributor.authorEspinoza, J.
dc.contributor.authorYoon, B. H.
dc.contributor.authorHassan, S. S.
dc.date.accessioned2023-05-18T19:49:36Z
dc.date.available2023-05-18T19:49:36Z
dc.date.issued2007
dc.description.abstractAims: Adiponectin is an adipokine with insulin-sensitizing, anti-atherogenic, anti-inflammatory and angiogenic properties. The aims of this study were to determine whether maternal plasma adiponectin concentrations differ between patients with severe preeclampsia and those with normal pregnancies, and to explore the relationship between plasma adiponectin and the results of Doppler velocimetry of the uterine arteries. Methods: This case-control study included two groups: (1) patients with severe preeclampsia (ns50) and (2) patients with normal pregnancies (ns150). Pulsedwave and color Doppler ultrasound examination of the uterine arteries were performed. Plasma adiponectin concentrations were determined by ELISA. Non-parametric statistics were used for analysis. Results: (1) Patients with severe preeclampsia had a higher median plasma concentration of adiponectin than that of normal pregnant women. (2) The median plasma adiponectin concentration did not differ between women with severe preeclampsia who had a high impedance to blood flow in the uterine arteries and those with normal impedance to blood flow. (3) Among patients with normal pregnancies, plasma adiponectin concentrations were negatively correlated with BMI in the first trimester and at sampling. Conclusions: Women with severe preeclampsia have a higher median plasma concentration of adiponectin than that of normal pregnant women. This may reflect a compensatory feedback mechanism to the metabolicallyaltered, anti-angiogenic and pro-atherogenic state of severe preeclampsia.
dc.format.extent10 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1515/JPM.2007.121
dc.identifier.issn1619-3997
dc.identifier.urihttps://doi.org/10.1515/JPM.2007.121
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-36849050212&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/67059
dc.information.autorucEscuela de Medicina; Kusanovic, Juan Pedro; 0000-0003-0640-2070; 1008900
dc.information.autorucEscuela de Medicina; Gómez Mora, Ricardo Alberto; 0000-0001-9267-304X; 80926
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final512
dc.pagina.inicio503
dc.revistaJournal of Perinatal Medicine
dc.rightsacceso abierto
dc.subjectAdiponectin
dc.subjectDoppler
dc.subjectObesity
dc.subjectPreeclampsia
dc.subjectPregnancy
dc.subjectUterine artery
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleAdiponectin in severe preeclampsia
dc.typeartículo
dc.volumen35
sipa.codpersvinculados1008900
sipa.codpersvinculados80926
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