Cardiac function in critically ill patients with severe COVID: A prospective cross-sectional study in mechanically ventilated patients

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dc.article.number154166
dc.contributor.authorValenzuela E.D.
dc.contributor.authorGonzalez A.
dc.contributor.authorRovegno M.
dc.contributor.authorRamirez J.
dc.contributor.authorHernandez G.
dc.contributor.authorBruhn A.
dc.contributor.authorBakker J.
dc.contributor.authorMercado P.
dc.contributor.authorAguilera J.
dc.contributor.authorPairumani R.
dc.contributor.authorPetruska E.
dc.contributor.authorMorales F.
dc.contributor.authorAraya C.
dc.contributor.authorMedel J.N.
dc.contributor.authorUgalde D.
dc.contributor.authorEisen D.
dc.contributor.authorMontoya J.
dc.contributor.authorSlama M.
dc.date.accessioned2024-01-10T12:37:17Z
dc.date.available2024-01-10T12:37:17Z
dc.date.issued2022
dc.description.abstract© 2022 Elsevier Inc.Purpose: To evaluate cardiac function in mechanically ventilated patients with COVID-19. Materials and methods: Prospective, cross-sectional multicenter study in four university-affiliated hospitals in Chile. All consecutive patients with COVID-19 ARDS requiring mechanical ventilation admitted between April and July 2020 were included. We performed systematic transthoracic echocardiography assessing right and left ventricular function within 24 h of intubation. Results: 140 patients aged 57 ± 11, 29% female were included. Cardiac output was 5.1 L/min [IQR 4.5–6.2] and 86% of the patients required norepinephrine. ICU mortality was 29% (40 patients). Fifty-four patients (39%) exhibited right ventricle dilation out of whom 20 patients (14%) exhibited acute cor pulmonale (ACP). Eight out of the twenty patients with ACP exhibited pulmonary embolism (40%). Thirteen patients (9%) exhibited left ventricular systolic dysfunction (ejection fraction <45%). In the multivariate analysis acute cor pulmonale and PaO2/FiO2 ratio were independent predictors of ICU mortality. Conclusions: Right ventricular dilation is highly prevalent in mechanically ventilated patients with COVID-19 ARDS. Acute cor pulmonale was associated with reduced pulmonary function and, in only 40% of patients, with co-existing pulmonary embolism. Acute cor pulmonale is an independent risk factor for ICU mortality.
dc.fechaingreso.objetodigital27-03-2024
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.jcrc.2022.154166
dc.identifier.eissn1557-78615
dc.identifier.issn15578615 08839441
dc.identifier.pubmedid36244256
dc.identifier.scopusidSCOPUS_ID:85139724863
dc.identifier.urihttps://doi.org/10.1016/j.jcrc.2022.154166
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76804
dc.information.autorucFacultad de Medicina; Rovegno Echavarria, David Maximiliano; S/I; 1004053
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherW.B. Saunders
dc.relation.ispartofJournal of Critical Care
dc.revistaJournal of Critical Care
dc.rightsacceso restringido
dc.subjectAcute cor pulmonale
dc.subjectCardiac function
dc.subjectCOVID-19
dc.subjectMechanical ventilation
dc.subjectMortality
dc.subjectRight ventricular dilation
dc.titleCardiac function in critically ill patients with severe COVID: A prospective cross-sectional study in mechanically ventilated patients
dc.typeartículo
dc.volumen72
sipa.codpersvinculados1004053
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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