Potential impact on estimated treatment effects of information lost to follow-up in randomised controlled trials (LOST-IT): systematic review

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dc.contributor.authorAkl, Elie A.
dc.contributor.authorBriel, Matthias
dc.contributor.authorYou, John J.
dc.contributor.authorSun, Xin
dc.contributor.authorJohnston, Bradley C.
dc.contributor.authorBusse, Jason W.
dc.contributor.authorMulla, Sohail
dc.contributor.authorLamontagne, Francois
dc.contributor.authorBassler, Dirk
dc.contributor.authorVera, Claudio
dc.contributor.authorAlshurafa, Mohamad
dc.contributor.authorKatsios, Christina M.
dc.contributor.authorZhou, Qi
dc.contributor.authorCukierman Yaffe, Tali
dc.contributor.authorGangji, Azim
dc.contributor.authorMills, Edward J.
dc.contributor.authorWalter, Stephen D.
dc.contributor.authorCook, Deborah J.
dc.contributor.authorSchuenemann, Holger J.
dc.contributor.authorAltman, Douglas G.
dc.contributor.authorGuyatt, Gordon H.
dc.date.accessioned2024-01-10T13:16:26Z
dc.date.available2024-01-10T13:16:26Z
dc.date.issued2012
dc.description.abstractObjective To assess the reporting, extent, and handling of loss to follow-up and its potential impact on the estimates of the effect of treatment in randomised controlled trials.
dc.description.abstractDesign Systematic review. We calculated the percentage of trials for which the relative risk would no longer be significant under a number of assumptions about the outcomes of participants lost to follow-up.
dc.description.abstractData sources Medline search of five top general medical journals, 2005-07.
dc.description.abstractEligibility criteria Randomised controlled trials that reported a significant binary primary patient important outcome.
dc.description.abstractResults Of the 235 eligible reports identified, 31 (13%) did not report whether or not loss to follow-up occurred. In reports that did give the relevant information, the median percentage of participants lost to follow-up was 6% (interquartile range 2-14%). The method by which loss to follow-up was handled was unclear in 37 studies (19%); the most commonly used method was survival analysis (66, 35%). When we varied assumptions about loss to follow-up, results of 19% of trials were no longer significant if we assumed no participants lost to follow-up had the event of interest, 17% if we assumed that all participants lost to follow-up had the event, and 58% if we assumed a worst case scenario (all participants lost to follow-up in the treatment group and none of those in the control group had the event). Under more plausible assumptions, in which the incidence of events in those lost to follow-up relative to those followed-up is higher in the intervention than control group, results of 0% to 33% trials were no longer significant.
dc.description.abstractConclusion Plausible assumptions regarding outcomes of patients lost to follow-up could change the interpretation of results of randomised controlled trials published in top medical journals.
dc.description.funderPfizer
dc.description.funderSwiss National Foundation
dc.description.funderRoche Research Foundation
dc.description.funderOntario Ministry of Health and Long-Term Care
dc.description.funderNational Natural Science Foundation of China
dc.description.funderSickKids Foundation
dc.description.funderCIHR
dc.description.funderCanadian Chiropractic Research Foundation
dc.description.funderKidney Foundation of Canada/Canadian Society of Nephrology
dc.description.funderCancer Research UK
dc.fechaingreso.objetodigital2024-05-06
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1136/bmj.e2809
dc.identifier.issn1756-1833
dc.identifier.pubmedidMEDLINE:22611167
dc.identifier.urihttps://doi.org/10.1136/bmj.e2809
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78585
dc.identifier.wosidWOS:000304359600008
dc.information.autorucMedicina;Vera C ;S/I;687
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherBMJ PUBLISHING GROUP
dc.revistaBMJ-BRITISH MEDICAL JOURNAL
dc.rightsacceso abierto
dc.subjectINTENTION-TO-TREAT
dc.subjectANTIRETROVIRAL TREATMENT
dc.subjectMETHODOLOGICAL QUALITY
dc.subjectMISSING-DATA
dc.subjectPROGRAMS
dc.subjectOUTCOMES
dc.subjectBIAS
dc.subjectMETAANALYSIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePotential impact on estimated treatment effects of information lost to follow-up in randomised controlled trials (LOST-IT): systematic review
dc.typeartículo
dc.volumen344
sipa.codpersvinculados687
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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