Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens

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dc.contributor.authorPardhi, Dinesh M.
dc.contributor.authorKaraman, Didem Sen
dc.contributor.authorTimonen, Juri
dc.contributor.authorWu, Wei
dc.contributor.authorZhang, Qi
dc.contributor.authorSatija, Saurabh
dc.contributor.authorMehta, Meenu
dc.contributor.authorCharbe, Nitin
dc.contributor.authorMcCarron, Paul A.
dc.contributor.authorTambuwala, Murtaza M.
dc.contributor.authorBakshi, Hamid A.
dc.contributor.authorNegi, Poonam
dc.contributor.authorAljabali, Alaa A.
dc.contributor.authorDua, Kamal
dc.contributor.authorChellappan, Dinesh K.
dc.contributor.authorBehera, Ajit
dc.contributor.authorPathak, Kamla
dc.contributor.authorWatharkar, Ritesh B.
dc.contributor.authorRautio, Jarkko
dc.contributor.authorRosenholm, Jessica M.
dc.date.accessioned2025-01-23T19:49:13Z
dc.date.available2025-01-23T19:49:13Z
dc.date.issued2020
dc.description.abstractThis review details the antimicrobial applications of inorganic nanomaterials of mostly metallic form, and the augmentation of activity by surface conjugation of peptide ligands. The review is subdivided into three main sections, of which the first describes the antimicrobial activity of inorganic nanomaterials against gram-positive, gram-negative and multidrug-resistant bacterial strains. The second section highlights the range of antimicrobial peptides and the drug resistance strategies employed by bacterial species to counter lethality. The final part discusses the role of antimicrobial peptide-decorated inorganic nanomaterials in the fight against bacterial strains that show resistance. General strategies for the preparation of antimicrobial peptides and their conjugation to nanomaterials are discussed, emphasizing the use of elemental and metallic oxide nanomaterials. Importantly, the permeation of antimicrobial peptides through the bacterial membrane is shown to aid the delivery of nanomaterials into bacterial cells. By judicious use of targeting ligands, the nanomaterial becomes able to differentiate between bacterial and mammalian cells and, thus, reduce side effects. Moreover, peptide conjugation to the surface of a nanomaterial will alter surface chemistry in ways that lead to reduction in toxicity and improvements in biocompatibility.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ijpharm.2020.119531
dc.identifier.eissn1873-3476
dc.identifier.issn0378-5173
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2020.119531
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100488
dc.identifier.wosidWOS:000557910200009
dc.language.isoen
dc.revistaInternational journal of pharmaceutics
dc.rightsacceso restringido
dc.subjectNanomaterial
dc.subjectAntimicrobial
dc.subjectConjugates
dc.subjectAntimicrobial peptides
dc.subjectAntibiotics
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAnti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens
dc.typeartículo
dc.volumen586
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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