Prenatal growth and metabolic syndrome components among Chilean children

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dc.contributor.authorMardones, F.
dc.contributor.authorVillarroel, L.
dc.contributor.authorArnaiz, P.
dc.contributor.authorBarja, S.
dc.contributor.authorDominguez, A.
dc.contributor.authorCastillo, O.
dc.contributor.authorFarias, M.
dc.contributor.authorEriksson, J. G.
dc.contributor.authorPacheco, P.
dc.date.accessioned2024-01-10T12:07:39Z
dc.date.available2024-01-10T12:07:39Z
dc.date.issued2012
dc.description.abstractThe association of prenatal growth with metabolic syndrome (MS) components and insulin resistance (IR) in children has not been studied in Chile and most developing countries. Some associations found in developed countries are controversial. A retrospective cohort study was designed linking present information on MS components and IR in children with register-based information on birth weight (BW), birth length (BL) and gestational age (GA). Examinations included anthropometry and blood pressure (BP), as well as self-report of pubertal status. A fasting blood sample was taken to determine lipids, glucose, insulin and homeostasis model assessment (HOMA)-IR was calculated. The study cohort of 2152 children was on average 11.4 +/- 1.0 years old. The prevalence of MS, IR and overweight were 7.6%, 24.5% and 34%, respectively. Elevated BP was negatively associated with dichotomized risk categories of the perinatal factors studied (BW, BL and GA). Contingency tables showed that high waist circumference (WC) and elevated BP had a U-shaped association with various categories of BW and BL, respectively. Stepwise linear regressions selected: (a) WC as inversely associated to GA and directly associated to BW, (b) BP as inversely associated to GA and (c) HOMA-IR as inversely associated to BL. Non-optimal prenatal growth seems to predispose to high WC, elevated BP and IR in school-age children, supporting the early life origin of several non-communicable diseases. Those associations were rather weak as estimated by the slopes of the regressions and probably reduced by their U-shaped nature; they would reasonably become stronger with a longer follow-up.
dc.description.funderFONDECYT (National Fund for Science and Technology, Chile)
dc.fechaingreso.objetodigital2024-04-23
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1017/S2040174412000207
dc.identifier.eissn2040-1752
dc.identifier.issn2040-1744
dc.identifier.pubmedidMEDLINE:25102145
dc.identifier.urihttps://doi.org/10.1017/S2040174412000207
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76309
dc.identifier.wosidWOS:000307183400004
dc.information.autorucMedicina;Arnaiz P ;S/I;98982
dc.information.autorucMedicina;Barja S ;S/I;64532
dc.information.autorucMedicina;Castillo O ;S/I;1000391
dc.information.autorucMedicina;Dominguez A ;S/I;74622
dc.information.autorucMedicina;Mardones F ;S/I;98805
dc.information.autorucEducación;Pacheco P ;S/I;196056
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final244
dc.pagina.inicio237
dc.publisherCAMBRIDGE UNIV PRESS
dc.revistaJOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
dc.rightsacceso restringido
dc.subjectchildren
dc.subjectinsulin resistance
dc.subjectmetabolic syndrome
dc.subjectprenatal growth
dc.subjectretrospective cohort
dc.subjectBIRTH-WEIGHT
dc.subjectBLOOD-PRESSURE
dc.subjectINSULIN-RESISTANCE
dc.subjectABDOMINAL OBESITY
dc.subjectBODY-SIZE
dc.subjectRISK-FACTORS
dc.subjectADOLESCENTS
dc.subjectPREVALENCE
dc.subjectGLUCOSE
dc.subjectHEALTH
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titlePrenatal growth and metabolic syndrome components among Chilean children
dc.typeartículo
dc.volumen3
sipa.codpersvinculados98982
sipa.codpersvinculados64532
sipa.codpersvinculados1000391
sipa.codpersvinculados74622
sipa.codpersvinculados98805
sipa.codpersvinculados196056
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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