Strategies to reduce infections and antibiotic use and its effects in a neonatal care unit

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dc.contributor.authorUrzua, Soledad
dc.contributor.authorFerres, Marcela
dc.contributor.authorGarcia, Patricia
dc.contributor.authorSanchez, Amparo
dc.contributor.authorLuco, Matias
dc.date.accessioned2024-01-10T14:21:44Z
dc.date.available2024-01-10T14:21:44Z
dc.date.issued2017
dc.description.abstractIntroduction: Late onset sepsis (LOS) remains an important cause of morbidity and mortality in neonatal intensive care units (NICU). The empirical use of vancomycin and other broad spectrum antibiotics is very frequent and is associated with the emergence of resistant agents, infection by gram-negative bacilli (GNB), fungal infections and increased morbidity and mortality. Objective: To evaluate the impact of 5 intervention protocols designed to reduce infections and promote the rational use of antibiotics (AB) in a single NICU. Patients and Method: Retrospective analysis included all hospitalized patients before (year 2012) and after interventions (August 2013 through July 2014). All episodes of positive cultures (blood, urine, tracheal and spinal fluid) were considered as late onset infections. Results: After intervention, a significant decrease of late onset infections was observed from 14.3 to 8.5 per 1,000 live births (p < 0.01); with a decrease in LOS from 5.7 to 2.9 per 1,000 live births, although no significant. There was a decrease in vancomycin and 3rd generation cephalosporin use without Candida spp infections in the intervention period. Mortality rates and length of hospital stay were similar in both study periods. Conclusion: After interventions, there was an important reduction in overall late onset infections and AB related costs.
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.eissn0717-6341
dc.identifier.issn0716-1018
dc.identifier.pubmedidMEDLINE:28632822
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79767
dc.identifier.wosidWOS:000400803900001
dc.information.autorucMedicina;Ferres M;S/I;66180
dc.information.autorucMedicina;Garcia P;S/I;73909
dc.information.autorucMedicina;Luco M;S/I;7023
dc.information.autorucMedicina;Urzua S;S/I;135691
dc.issue.numero2
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final107
dc.pagina.inicio99
dc.publisherSOC CHILENA INFECTOLOGIA
dc.revistaREVISTA CHILENA DE INFECTOLOGIA
dc.rightsregistro bibliográfico
dc.subjectAntibiotic stewardship
dc.subjectbloodstream infection
dc.subjectInfection control
dc.subjectMultidrug resistance
dc.subjectNeonate
dc.subjectNICU
dc.subjectLATE-ONSET SEPSIS
dc.subjectBLOOD-STREAM INFECTION
dc.subjectBIRTH-WEIGHT INFANTS
dc.subjectREJECTION CRITERIA
dc.subjectRISK-FACTORS
dc.subjectEMPIRIC USE
dc.subjectVANCOMYCIN
dc.subjectRATES
dc.subjectCOLONIZATION
dc.subjectSTEWARDSHIP
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStrategies to reduce infections and antibiotic use and its effects in a neonatal care unit
dc.typeartículo
dc.volumen34
sipa.codpersvinculados66180
sipa.codpersvinculados73909
sipa.codpersvinculados7023
sipa.codpersvinculados135691
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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