Spectroscopic Properties and Biocompatibility Studies of CdTe Quantum Dots Capped with Biological Thiols

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dc.contributor.authorDiaz, V.
dc.contributor.authorRamirez Maureira, M.
dc.contributor.authorMonras, J. P.
dc.contributor.authorVargas, J.
dc.contributor.authorBravo, D.
dc.contributor.authorOsorio Roman, I. O.
dc.contributor.authorVasquez, C. C.
dc.contributor.authorPerez Donoso, J. M.
dc.date.accessioned2024-01-10T12:42:55Z
dc.date.available2024-01-10T12:42:55Z
dc.date.issued2012
dc.description.abstractCdTe quantum dots (QDs) capped with two relevant biological thiols, glutathione (GSH) or cysteine (Cys) were synthesized in aqueous solution using CdCl2, K2TeO3 and NaBH4 and their chemical, spectroscopic and biocompatibility properties were assessed. Synthesized nanoparticles (NPs) are 3-6 nm in diameter, with emission spectra between 480-580 nm depending on QDs size, and emission quantum yields between 0.35-0.65. The toxicity of thiol-capped CdTe NPs to different bacterial strains was determined. Increased biocompatibility for Cys-capped QDs was observed. In addition, QDs uptake by eukaryotic cells was evaluated by fluorescence microscopy. CdTe-GSH NPs were incorporated into MKN45 cells only in the presence of lipofectamine. On the other hand, although CdTe-Cys NPs were freely incorporated into these cells, the amount of incorporation as well as the number of fluorescent cells was lower than that observed with GSH-capped QDs. Finally, no significant changes in cell morphology as a consequence of GSH- or Cys-capped QDs incorporation were observed. Summarizing, our results indicate that the as-synthesized GSH- and Cys-capped QDs display differential spectroscopic properties and cellular interactions, being CdTe-Cys more biocompatible than CdTe-GSH NPs.
dc.description.funderFONDECYT (Fondo Nacional de Investigacion Cientifica y Tecnologica)
dc.description.funderDicyt-USACH
dc.description.funderIFS
dc.description.funderCONICYT (Comision Nacional de Ciencia y Tecnologia)
dc.fechaingreso.objetodigital2024-05-20
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1166/sam.2012.1327
dc.identifier.eissn1947-2943
dc.identifier.issn1947-2935
dc.identifier.urihttps://doi.org/10.1166/sam.2012.1327
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77551
dc.identifier.wosidWOS:000306256400012
dc.information.autorucQuímica;Osorio I;S/I;207713
dc.issue.numero5-6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final616
dc.pagina.inicio609
dc.publisherAMER SCIENTIFIC PUBLISHERS
dc.revistaSCIENCE OF ADVANCED MATERIALS
dc.rightsacceso restringido
dc.subjectCdTe
dc.subjectQuantum Dots
dc.subjectCapped-Agent
dc.subjectBiocompatible Nanoparticles
dc.subjectSHAPE CONTROL
dc.subjectNANOCRYSTALS
dc.subjectCELLS
dc.subjectRESISTANCE
dc.subjectTOXICITY
dc.subjectCADMIUM
dc.subjectCDSE
dc.titleSpectroscopic Properties and Biocompatibility Studies of CdTe Quantum Dots Capped with Biological Thiols
dc.typeartículo
dc.volumen4
sipa.codpersvinculados207713
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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