Relationship between mechanical and metabolic dyssynchrony with left bundle branch block: Evaluation by 18-fluorodeoxyglucose positron emission tomography in patients with non-ischemic heart failure

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dc.contributor.authorCastro, Pablo
dc.contributor.authorLuis Winter, Jose
dc.contributor.authorVerdejo, Hugo
dc.contributor.authorOrellana, Pilar
dc.contributor.authorCarlos Quintana, Juan
dc.contributor.authorGreig, Douglas
dc.contributor.authorEnriquez, Andres
dc.contributor.authorSepulveda, Luis
dc.contributor.authorConcepcion, Roberto
dc.contributor.authorSepulveda, Pablo
dc.contributor.authorRossel, Victor
dc.contributor.authorChiong, Mario
dc.contributor.authorGarcia, Lorena
dc.contributor.authorLavandero, Sergio
dc.date.accessioned2024-01-10T12:08:07Z
dc.date.available2024-01-10T12:08:07Z
dc.date.issued2012
dc.description.abstractBACKGROUND: Ventricular dyssynchrony is a common finding in patients with heart failure (HF), especially in the presence of conduction delays. The loss of ventricular synchrony leads to progressive impairment of contractile function, which may be explained in part by segmental abnormalities of myocardial metabolism. However, the association of these metabolic disarrangements with parameters of ventricular dyssynchrony and electrocardiography (ECG) findings has not yet been studied.
dc.description.abstractMETHODS: Our aim was to determine the correlation between the presence of left bundle branch block (LBBB) with left ventricular (LV) mechanical synchrony assessed by multiple-gated acquisition scan (MUGA) and with patterns of 18-fluorodeoxyglucose ((18)FDG) uptake in patients with non-ischemic heart failure. Twenty-two patients with non-ischemic cardiomyopathy, LV ejection fraction (LVEF) <= 45% and New York Heart Association (NYHA) Functional Class II or III symptoms under standard medical therapy were included, along with 10 healthy controls matched for age and gender. A 12-lead ECG was obtained to measure the length of the QRS. Mechanical LV synchrony was assessed by MUGA using phase analysis. All patients and controls underwent positron emission tomography with (18)FDG to determine the distribution of myocardial glucose uptake. The standard deviation of peak (18)FDG uptake was used as an index of metabolic heterogeneity. Student's t-test and Pearson's correlation were used for statistical analysis.
dc.description.abstractRESULTS: The mean age of the patients with HF was 54 +/- 12 years and 72% were male. The length of the QRS was 129 +/- 31 milliseconds and LBBB was present in 9 patients. Patients with HF had decreased LV (18)FDG uptake compared with controls (7.56 +/- 3.36 vs 11.63 +/- 4.55 standard uptake value; p = 0.03). The length of the QRS interval correlated significantly with glucose uptake heterogeneity (r = 0.62; p = 0.002) and mechanical dyssynchrony (r = 0.63; p = 0.006). HF patients with LBBB showed marked glucose uptake heterogeneity compared with HF patients without LBBB (41.4 +/- 10 vs 34.7 +/- 4.9 ml/100 g/min, respectively; p = 0.01).
dc.description.abstractCONCLUSIONS: Patients with non-ischemic heart failure exhibit a global decrease in myocardial glucose uptake. Within this group, subjects who also have LBBB exhibit a marked heterogeneity in segmental glucose uptake, which directly correlates with QRS duration. J Heart Lung Transplant 2012;31:1096-101 (C) 2012 International Society for Heart and Lung Transplantation. All rights reserved.
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico
dc.description.funderFondo de Financiamiento de Centros de Excelencia en Investigacion (FONDAP)
dc.description.funderComision Nacional de Investigacion Cientifica Tecnologica
dc.fechaingreso.objetodigital25-03-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.healun.2012.07.002
dc.identifier.issn1053-2498
dc.identifier.pubmedidMEDLINE:22975099
dc.identifier.urihttps://doi.org/10.1016/j.healun.2012.07.002
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76360
dc.identifier.wosidWOS:000309085300006
dc.information.autorucMedicina; Verdejo H ;S/I;1001175
dc.information.autorucMedicina;Castro P ;S/I;100212
dc.information.autorucMedicina;Enriquez A;S/I;167308
dc.information.autorucMedicina;Greig D ;S/I;15418
dc.information.autorucMedicina;Quintana J;S/I;89709
dc.information.autorucMedicina;Winter J;S/I;15983
dc.issue.numero10
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1101
dc.pagina.inicio1096
dc.publisherELSEVIER SCIENCE INC
dc.revistaJOURNAL OF HEART AND LUNG TRANSPLANTATION
dc.rightsacceso restringido
dc.subjectmyocardial metabolism
dc.subjectPET
dc.subjectventricular dyssynchrony
dc.subjectCARDIAC-RESYNCHRONIZATION THERAPY
dc.subjectDILATED CARDIOMYOPATHY
dc.subjectIMPLANTABLE DEFIBRILLATOR
dc.subjectOXIDATIVE-METABOLISM
dc.subjectMYOCARDIAL-PERFUSION
dc.subjectGLUCOSE-METABOLISM
dc.subjectPHASE-ANALYSIS
dc.subjectFATTY-ACID
dc.subjectPET
dc.subjectDISEASE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRelationship between mechanical and metabolic dyssynchrony with left bundle branch block: Evaluation by 18-fluorodeoxyglucose positron emission tomography in patients with non-ischemic heart failure
dc.typeartículo
dc.volumen31
sipa.codpersvinculados1001175
sipa.codpersvinculados100212
sipa.codpersvinculados167308
sipa.codpersvinculados15418
sipa.codpersvinculados89709
sipa.codpersvinculados15983
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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