Cambios en el pronóstico a largo plazo de la hipertensión arterial pulmonar

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dc.contributor.authorEnriquez, Andres
dc.contributor.authorCastro, Pablo
dc.contributor.authorSepulveda, Pablo
dc.contributor.authorVerdejo, Hugo
dc.contributor.authorGreig, Douglas
dc.contributor.authorGabrielli, Luigi
dc.contributor.authorFerrada, Marcela
dc.contributor.authorLapostol, Carolina
dc.date.accessioned2024-01-10T13:11:37Z
dc.date.available2024-01-10T13:11:37Z
dc.date.issued2011
dc.description.abstractBackground: Pulmonary artery hypertension (PAR) is a progressive disease with high mortality. Major advances had been made in the treatment of this condition during the last decade. Aim: To characterize the clinical evolution and mortality of a cohort of Chilean patients. Material and Methods: Seventeen patients with PAH diagnosed in the last 10 years in two Chilean hospitals were enrolled. Measurements at diagnosis included hemodynamic variables and 6-minute walk test. The patients were followed clinically for 3 years and the observed mortality was compared with that predicted by the prognostic equation proposed by the historic registry of the National Institutes of Health (NIH). Results: The mean age of patients was 45 years and 80% had an idiopathic PAH. The mean median pulmonary artery pressure was 57 +/- 15 mmHg, the cardiac index was 2.4 +/- 0.7 l/min/m(2) and the right atrial pressure was 12 +/- 8 mmHg. The 6-minute walk distance was 348 +/- 98 m. All patients received anticoagulants. Eighty two percent received ambrisentan, 12% received bosentan, 29% received iloprost and 24% sildenafil. At the end of follow-up only 3 patients had died, with an observed survival rate of 88, 82 and 82% at 1, 2 and 3 years, respectively. In contrast, the survival calculated according to the predictive formula of the NIH was 67, 56 and 45%, respectively. Among surviving patients, an improvement in exercise capacity was observed after one year (p < 0.05). Conclusions: The observed survival rate was significantly better than that estimated according to historical data. Furthermore, therapy was associated with an improvement in functional capacity after one year. This prognostic improvement is consistent with data of other contemporary registries published after the NIH Registry. (Rev Med Chile 2011; 139: 327-333).
dc.fechaingreso.objetodigital2024-05-31
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0034-98872011000300007
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:21879164
dc.identifier.urihttps://doi.org/10.4067/S0034-98872011000300007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78073
dc.identifier.wosidWOS:000290372100007
dc.information.autorucMedicina;Castro P;S/I;100212
dc.information.autorucMedicina;Enriquez A ;S/I;167308
dc.information.autorucMedicina;Ferrada M ;S/I;89500
dc.information.autorucMedicina;Gabrielli L ;S/I;11086
dc.information.autorucMedicina;Greig D;S/I;15418
dc.information.autorucMedicina;Verdejo H ;S/I;1001175
dc.information.autorucFacultad de Medicina; Sepulveda Varela, Pablo Andres; S/I; 1095919
dc.issue.numero3
dc.language.isoes
dc.nota.accesoContenido parcial
dc.pagina.final333
dc.pagina.inicio327
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsacceso restringido
dc.subjectDrug therapy
dc.subjectHypertension
dc.subjectpulmonary
dc.subjectSurvival rate
dc.subjectDOUBLE-BLIND
dc.subjectSURVIVAL
dc.subjectTHERAPY
dc.subjectREGISTRY
dc.subjectTREPROSTINIL
dc.subjectPROSTACYCLIN
dc.subjectMULTICENTER
dc.subjectEFFICACY
dc.subjectINFUSION
dc.subjectBOSENTAN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCambios en el pronóstico a largo plazo de la hipertensión arterial pulmonar
dc.title.alternativeChanges long term prognosis of 17 patients with pulmonary artery hypertension
dc.typeartículo
dc.volumen139
sipa.codpersvinculados100212
sipa.codpersvinculados167308
sipa.codpersvinculados89500
sipa.codpersvinculados11086
sipa.codpersvinculados15418
sipa.codpersvinculados1001175
sipa.codpersvinculados1095919
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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