The Influence of Age on the Dynamic Relationship Between End-Tidal Sevoflurane Concentrations and Bispectral Index

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dc.contributor.authorCortinez, Luis I.
dc.contributor.authorTroconiz, Inaki F.
dc.contributor.authorFuentes, Ricardo
dc.contributor.authorGambus, Pedro
dc.contributor.authorHsu, Yung Wei
dc.contributor.authorAltermatt, Fernando
dc.contributor.authorMunoz, Hernan R.
dc.date.accessioned2024-01-10T12:43:50Z
dc.date.available2024-01-10T12:43:50Z
dc.date.issued2008
dc.description.abstractBACKGROUND: Age is an important determinant of the pharmacokinetic profile of inhaled anesthetics. The influence of age on the dynamic profile of sevoflurane's effect has not been well described. We performed this study to characterize the influence of age and other covariates on the dynamic relationship between sevoflurane end-tidal concentration (C-ET) and its effect measured by bispectral index (BIS).
dc.description.abstractMETHODS: Fifty patients, aged 3-71 yr, scheduled for minor surgery were prospectively studied. The BIS and sevoflurane C-ET were continuously measured during the study period. During maintenance of anesthesia and after stable BIS values of 60-65 were obtained, the inspired concentration of sevoflurane was increased to 5 vol % for 5 min or until BIS <40 and then decreased. The dynamic relationship between sevoflurane C-ET and its effect as measured by BIS during this transition period were modeled with an inhibitory E-max model using a population pharmacokinetic-pharmacodynamic approach with NONMEM V. A predictive check method was used to validate the final model.
dc.description.abstractRESULTS: The sensitivity to sevoflurane's effect as measured by BIS expressed in the C, [steady-state C-ET eliciting half of maximum response (I-max)] increased with age. The speed of change of sevoflurane's effect, expressed as the effect-site equilibration half-life (t(1/2) k(e0)), increased at older ages. The predictive check analysis confirmed the adequacy of the model.
dc.description.abstractCONCLUSIONS: Age significantly affects the dynamic relationship between sevoflurane C-ET and its effect measured with BIS.
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1213/ane.0b013e318181f013
dc.identifier.issn0003-2999
dc.identifier.pubmedidMEDLINE:18931213
dc.identifier.urihttps://doi.org/10.1213/ane.0b013e318181f013
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77626
dc.identifier.wosidWOS:000260397200017
dc.information.autorucMedicina;Altermatt F;S/I;7381
dc.information.autorucMedicina;Cortínez L;S/I;79356
dc.information.autorucMedicina;Fuentes R;S/I;91662
dc.information.autorucMedicina;Muñoz H;S/I;73573
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1572
dc.pagina.inicio1566
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaANESTHESIA AND ANALGESIA
dc.rightsacceso restringido
dc.subjectSPECTRAL EDGE FREQUENCY
dc.subjectISOFLURANE
dc.subjectANESTHESIA
dc.subjectPHARMACODYNAMICS
dc.subjectPHARMACOKINETICS
dc.subjectCHILDREN
dc.subjectNONMEM
dc.subjectEEG
dc.titleThe Influence of Age on the Dynamic Relationship Between End-Tidal Sevoflurane Concentrations and Bispectral Index
dc.typeartículo
dc.volumen107
sipa.codpersvinculados7381
sipa.codpersvinculados79356
sipa.codpersvinculados91662
sipa.codpersvinculados73573
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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