Effects of glucose-insulin-potassium solution on myocardial salvage and left ventricular function after primary angioplasty

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dc.contributor.authorCastro, PF
dc.contributor.authorLarrain, G
dc.contributor.authorBaeza, R
dc.contributor.authorCorbalan, R
dc.contributor.authorNazzal, C
dc.contributor.authorGreig, DP
dc.contributor.authorMiranda, FP
dc.contributor.authorPerez, O
dc.contributor.authorAcevedo, M
dc.contributor.authorMarchant, E
dc.contributor.authorOlea, E
dc.contributor.authorGonzalez, R
dc.date.accessioned2024-01-10T13:47:54Z
dc.date.available2024-01-10T13:47:54Z
dc.date.issued2003
dc.description.abstractObjective. To evaluate the effects of glucose-insulin-potassium (GIK) therapy on infarct size and left ventricular function when used as an adjuvant therapy to primary angioplasty.
dc.description.abstractDesign. Prospective, randomized, double-blind, placebo-controlled study.
dc.description.abstractSetting. Cardiac intensive care unit at a university hospital.
dc.description.abstractPatients. Thirty-seven patients with acute myocardial infarction for whom primary angioplasty was indicated.
dc.description.abstractInterventions. Eligible patients were randomized by a blinded pharmacist to GIK solution (30% glucose in water with insulin 50 U/L, and KCl 40 mM/L) vs. placebo at 1.5 mL/kg/hr for 24 hrs.
dc.description.abstractMeasurements and Main Results. Tc 99m sestamibi myocardial scintigraphy was performed at admission and at 3 months. Primary end points were the changes in left ventricular ejection fraction (LVEF) and the size of salvaged myocardium. Baseline clinical characteristics were similar in both groups. At the 3-month follow-up, a significant overall decrease in infarct size (37 +/- 16% vs. 12 +/- 10%, p < .005) and an increase in LVEF (34 +/- 13% vs. 49 +/- 9%, p =.005) were observed. Patients randomized to GIK solution experienced a significant increase in their LVEF at 3 months (39 +/- 12 to 51 +/- 13, p = .002). Patients who received placebo had no significant differences between baseline and 3-month measurements (44 +/- 13 vs. 49 +/- 14, p = NS). There was a trend toward an increase in myocardial salvage in the GIK group, which did not reach statistical significance. When patients from both groups were compared directly, differences in LVEF improvement were no longer significant.
dc.description.abstractConclusions. GIK solution did not improve LVEF or decrease the infarct size among patients undergoing primary angioplasty.
dc.fechaingreso.objetodigital2024-05-02
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/01.CCM.0000079604.46997.7B
dc.identifier.issn0090-3493
dc.identifier.pubmedidMEDLINE:12973173
dc.identifier.urihttps://doi.org/10.1097/01.CCM.0000079604.46997.7B
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79315
dc.identifier.wosidWOS:000184797600011
dc.information.autorucMedicina;Acevedo M;S/I;81173
dc.information.autorucMedicina;Castro P;S/I;100212
dc.information.autorucMedicina;Corbalán R;S/I;98700
dc.information.autorucMedicina;González R;S/I;98827
dc.issue.numero8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final2155
dc.pagina.inicio2152
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaCRITICAL CARE MEDICINE
dc.rightsacceso restringido
dc.subjectinsulin
dc.subjectglucose
dc.subjectpotassium
dc.subjectmyocardial infarction
dc.subjectangioplasty
dc.subjectPERFUSION SPECT
dc.subjectFATTY-ACIDS
dc.subjectINFARCTION
dc.subjectTRIAL
dc.subjectTHERAPY
dc.subjectARRHYTHMIAS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffects of glucose-insulin-potassium solution on myocardial salvage and left ventricular function after primary angioplasty
dc.typeartículo
dc.volumen31
sipa.codpersvinculados81173
sipa.codpersvinculados100212
sipa.codpersvinculados98700
sipa.codpersvinculados98827
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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