Time course of antibody response to tetanus toxoid and pneumococcal capsular polysaccharides in patients infected with HIV

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dc.contributor.authorTalesnik, E
dc.contributor.authorVial, PA
dc.contributor.authorLabarca, J
dc.contributor.authorMendez, C
dc.contributor.authorSoza, X
dc.date.accessioned2024-01-10T13:43:57Z
dc.date.available2024-01-10T13:43:57Z
dc.date.issued1998
dc.description.abstractThe temporal course of the humoral immune response to T-cell-dependent and T-cell-independent type 2 antigens was evaluated in HIV-infected patients. In all, 26 seropositive patients were vaccinated with tetanus toroid and 23-valent pneumococcal vaccines; total IgG and IgG1 antibodies to tetanus toroid (Ttox) and total IgG and IgG2 antibodies against 23 Streptococcus pneumoniae capsular antigens (PPS) were measured at baseline, 2 months, and 12 months after vaccination. For the Ttox, baseline levels of IgG1 (Ttox-IgG1) increased from 11.0 to 19.5 mg/L at 2 months postimmunization. Overall only 6 patients (23%) showed a significant response. At 12 months postvaccination, Ttox-IgG and T-tox-IgG1 were significantly lower than baseline levels (Ttox IgG basal; 11.0 mg/L, 12 months; 0.8 mg/L, Ttox IgG1 baseline; 13.1 mg/L, Ttox IgG1 12 months; 2.4 mg/L) and in 10 patients, antibodies that fell below protective levels (0.6 mg/L). In contrast with PPS, a significant response was observed at 2 and 12 months (PPS-IgG basal; 35.9 U/ml, 2 months; 151.4 U/ml, 12 months; 59.7 U/ml; PPS-IgG2 baseline 20.3 U/ml, 2 months; 113.2 U/ml, 12 months; 51..9 U/ml). Overall, 19 patients (76%) showed an immune response to pneumococcal polysaccharides antigens. Immunization with the Ttox T-cell-dependent antigen fails to elicit a significant immune response and may induce inhibition of antibody production in HIV-infected patients. In contrast, immunization with a T-cell-independent type 2 antigen can cause the pneumococcal polysaccharides to induce significant immune response in a high proportion of HIV-infected patients.
dc.fechaingreso.objetodigital2024-05-02
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/00042560-199812150-00005
dc.identifier.issn1077-9450
dc.identifier.pubmedidMEDLINE:9859960
dc.identifier.urihttps://doi.org/10.1097/00042560-199812150-00005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78801
dc.identifier.wosidWOS:000077424500005
dc.information.autorucMedicina;Talesnik E;S/I;99067
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final477
dc.pagina.inicio471
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaJOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
dc.rightsacceso restringido
dc.subjecttetanus toxoid
dc.subjectpneumococcal capsular polysaccharides
dc.subjectantibody response
dc.subjectHIV
dc.subjectAIDS
dc.subjectChile
dc.subjectHUMAN-IMMUNODEFICIENCY-VIRUS
dc.subjectIMMUNE-DEFICIENCY SYNDROME
dc.subjectAIDS-RELATED COMPLEX
dc.subjectSTREPTOCOCCUS-PNEUMONIAE
dc.subjectBACTERIAL PNEUMONIA
dc.subjectFLOW-CYTOMETRY
dc.subjectIGG ANTIBODY
dc.subjectSUBCLASS
dc.subjectLYMPHOCYTES
dc.subjectVACCINATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTime course of antibody response to tetanus toxoid and pneumococcal capsular polysaccharides in patients infected with HIV
dc.typeartículo
dc.volumen19
sipa.codpersvinculados99067
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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