VENTILATORY DRIVE AND RESPIRATORY MUSCLE FUNCTION IN PREGNANCY

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dc.contributor.authorCONTRERAS, G
dc.contributor.authorGUTIERREZ, M
dc.contributor.authorBEROIZA, T
dc.contributor.authorFANTIN, A
dc.contributor.authorODDO, H
dc.contributor.authorVILLARROEL, L
dc.contributor.authorCRUZ, E
dc.contributor.authorLISBOA, C
dc.date.accessioned2024-01-10T12:10:50Z
dc.date.available2024-01-10T12:10:50Z
dc.date.issued1991
dc.description.abstractIt has been demonstrated that during pregnancy expiratory reserve volume (ERV) decreases and minute ventilation (VE) increases initially and then stabilizes. In order to determine the role of thoracoabdominal mechanics, control of breathing, and inspiratory muscle function in these alterations, we studied inspiratory pressures, lung volumes, thoracic configuration, and respiratory drive in 18 normal pregnant women at Weeks 13, 21, 30, and 37 of pregnancy. Ten of them were studied 6 months after delivery. Transdiaphragmatic pressure (Pdi) was measured at Week 37 and 3 months after delivery in an additional group of seven women. VE as well as VT/Tl increased early during gestation and remained unchanged thereafter. In contrast, mouth occlusion pressure (P0.1) increased progressively during pregnancy, from 1.53 +/- 0.16 (mean +/- SE) to 2.02 +/- 0.18 cm H2O, and fell significantly to 1.1 +/- 0.15 cm H2O after delivery, indicating that effective respiratory impedance increases during pregnancy. Mean P0.1 correlated with progesterone plasma levels (r = 0.918 p < 0.05). No changes in Plmax, PEmax, and Pdi(max), were observed. End-expiratory gastric pressure (Pga) increases significantly during pregnancy: 11.8 +/- 0.8 versus 8.4 +/- 1.12 cm H2O after delivery (p < 0.012). This increment was correlated with the fall in ERV observed in late pregnancy (r = 0.74 p < 0.05). Our results demonstrate that during pregnancy ventilatory drive and respiratory impedance increase with the consequent stabilization of VE, but our data do not permit us to differentiate whether the increment in P0.1 is secondary to the increase in impedance or to the rise in progesterone. Respiratory muscle function remains normal despite the alteration of thoracic configuration.
dc.fechaingreso.objetodigital2024-05-20
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1164/ajrccm/144.4.837
dc.identifier.issn0003-0805
dc.identifier.pubmedidMEDLINE:1928958
dc.identifier.urihttps://doi.org/10.1164/ajrccm/144.4.837
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76609
dc.identifier.wosidWOS:A1991GJ50500020
dc.information.autorucMedicina;Cruz E;S/I;97822
dc.information.autorucMedicina;Lisboa C;S/I;98551
dc.information.autorucMedicina;Oddo H;S/I;98591
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final841
dc.pagina.inicio837
dc.publisherAMER LUNG ASSOC
dc.revistaAMERICAN REVIEW OF RESPIRATORY DISEASE
dc.rightsacceso restringido
dc.subjectOCCLUSION PRESSURE
dc.subjectPROGESTERONE
dc.subjectEXERCISE
dc.subjectREST
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleVENTILATORY DRIVE AND RESPIRATORY MUSCLE FUNCTION IN PREGNANCY
dc.typeartículo
dc.volumen144
sipa.codpersvinculados97822
sipa.codpersvinculados98551
sipa.codpersvinculados98591
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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