Altered Temporal Dynamics of Resting-State Functional Magnetic Resonance Imaging in Adolescent-Onset First-Episode Psychosis

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dc.article.number7248533
dc.catalogadorgrr
dc.contributor.authorMasias Bruns, Mireia
dc.contributor.authorRamírez Mahaluf, Juan Pablo
dc.contributor.authorValli, Isabel
dc.contributor.authorOrtuno, Maria
dc.contributor.authorIlzarbe, Daniel
dc.contributor.authorde la Serna, Elena
dc.contributor.authorNavarro, Olga Puig
dc.contributor.authorCrossley, Nicolás
dc.contributor.authorBallester, Miguel Angel Gonzalez
dc.contributor.authorBaeza, Inmaculada
dc.contributor.authorPiella, Gemma
dc.contributor.authorCastro-Fornieles, Josefina
dc.contributor.authorSugranyes, Gisela
dc.date.accessioned2023-10-12T20:30:01Z
dc.date.available2023-10-12T20:30:01Z
dc.date.issued2023
dc.description.abstractDynamic functional connectivity (dFC) alterations have been reported in patients with adult-onset and chronic psychosis. We sought to examine whether such abnormalities were also observed in patients with first episode, adolescent-onset psychosis (AOP), in order to rule out potential effects of chronicity and protracted antipsychotic treatment exposure. AOP has been suggested to have less diagnostic specificity compared to psychosis with onset in adulthood and occurs during a period of neurodevelopmental changes in brain functional connections. Study Design Seventy-nine patients with first episode, AOP (36 patients with schizophrenia-spectrum disorder, SSD; and 43 with affective psychotic disorder, AF) and 54 healthy controls (HC), aged 10 to 17 years were included. Participants underwent clinical and cognitive assessments and resting-state functional magnetic resonance imaging. Graph-based measures were used to analyze temporal trajectories of dFC, which were compared between patients with SSD, AF, and HC. Within patients, we also tested associations between dFC parameters and clinical variables. Study Results Patients with SSD temporally visited the different connectivity states in a less efficient way (reduced global efficiency), visiting fewer nodes (larger temporal modularity, and increased immobility), with a reduction in the metabolic expenditure (cost and leap size), relative to AF and HC (effect sizes: Cohen's D, ranging 0.54 to.91). In youth with AF, these parameters did not differ compared to HC. Connectivity measures were not associated with clinical severity, intelligence, cannabis use, or dose of antipsychotic medication. Conclusions dFC measures hold potential towards the development of brain-based biomarkers characterizing adolescent-onset SSD.
dc.fuente.origenWOS
dc.identifier.doi10.1093/schbul/sbad107
dc.identifier.eissn1745-1701
dc.identifier.issn0586-7614
dc.identifier.pubmedid37607335
dc.identifier.urihttps://doi.org/10.1093/schbul/sbad107
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75108
dc.identifier.wosidWOS:001051615100001
dc.information.autorucEscuela de Medicina; Ramírez Mahaluf, Juan Pablo; 0000-0002-0821-1174; 17132
dc.information.autorucEscuela de Medicina; Crossley, Nicolás ; 0000-0002-3060-656X; 11224
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final9
dc.pagina.inicio1
dc.publisherOxford Univ. Press
dc.revistaSCHIZOPHRENIA BULLETIN
dc.rightsacceso restringido
dc.subjectAdolescent onset-psychosis
dc.subjectResting-state fMRI
dc.subjectTemporal connectivity patterns
dc.subjectGraph analysis
dc.subjectDynamic functional connectivity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAltered Temporal Dynamics of Resting-State Functional Magnetic Resonance Imaging in Adolescent-Onset First-Episode Psychosis
dc.typeartículo
sipa.codpersvinculados17132
sipa.codpersvinculados11224
sipa.indexWOS
sipa.trazabilidadWOS;2023-09-09
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