p16ink4a Expression in Benign and Malignant Melanocytic Conjunctival Lesions

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dc.contributor.authorZoroquiain, Pablo
dc.contributor.authorFernandes, Bruno F.
dc.contributor.authorGonzalez, Sergio
dc.contributor.authorNovais, Gustavo N.
dc.contributor.authorSchalper, Kurt A.
dc.contributor.authorBurnier, Miguel N., Jr.
dc.date.accessioned2024-01-10T13:51:43Z
dc.date.available2024-01-10T13:51:43Z
dc.date.issued2012
dc.description.abstractAcquired conjunctival melanocytic lesions include nevi, primary acquired melanoses (PAMs), and melanomas. Conjunctival melanoma is a malignant melanocytic neoplasm with a high metastasis and mortality rate. Usually, the diagnosis can be achieved only with routine microscopic analysis, but in some cases, the samples are small or have artifacts. In these cases, complementary studies will be helpful, but currently, there are no well-understood or studied complementary methods. Objective. To analyze the immunohistochemical expression of p16 in conjunctival melanocytic lesions and to assess its potential for differentiating between benign and malignant melanocytic lesions. Methods. Immunohistochemical study against p16ink4a (p16) was performed on paraffin-embedded sections on 45 melanocytic lesions (9 melanomas, 19 nevi, and 2 PAMs with atypia and 15 without atypia). Expression was scored according to the German immunoreactive score (IRS). Results. Expression of p16 IRS differed between nevi, PAMs, and melanomas. The mean IRS for melanomas was 3.3 +/- 1.8 and was lower than those for nevi (7.63 +/- 3.24; P < .05), PAM with atypia (12 +/- 0; P < .05), and PAM without atypia (11 +/- 1.69; P < .05). Lesions with infiltration depths lower than 2 mm showed higher levels of p16. There were no differences between favorable and unfavorable locations. Conclusion. p16 Expression in conjunctival melanocytic lesions showed an expression similar to that in skin and seems to be a good marker to differentiate nevi and PAMs from melanomas. However, additional studies of larger series and follow-up are needed to confirm these findings.
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1177/1066896911435697
dc.identifier.issn1066-8969
dc.identifier.pubmedidMEDLINE:22287653
dc.identifier.urihttps://doi.org/10.1177/1066896911435697
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79621
dc.identifier.wosidWOS:000304699400003
dc.information.autorucMedicina;Gonzalez S;S/I;99856
dc.information.autorucMedicina;Schalper K;S/I;151783
dc.information.autorucMedicina;Zoroquiain P;S/I;175130
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final245
dc.pagina.inicio240
dc.publisherSAGE PUBLICATIONS INC
dc.revistaINTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
dc.rightsacceso restringido
dc.subjectconjunctival melanoma
dc.subjectconjunctival nevus
dc.subjectconjunctival tumor
dc.subjectp16ink4a
dc.subjectprimary acquired melanosis
dc.subjectBRAF MUTATIONS
dc.subjectMELANOMA
dc.subjectCANCER
dc.subjectTUMORS
dc.subjectP16
dc.subjectGENE
dc.subjectDIFFERENTIATE
dc.subjectMETASTASIS
dc.subjectBIOMARKERS
dc.subjectRECEPTORS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlep16ink4a Expression in Benign and Malignant Melanocytic Conjunctival Lesions
dc.typeartículo
dc.volumen20
sipa.codpersvinculados99856
sipa.codpersvinculados151783
sipa.codpersvinculados175130
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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