Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)

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dc.contributor.authorWeil, Alexander G.
dc.contributor.authorDimentberg, Evan
dc.contributor.authorLewis, Evan
dc.contributor.authorIbrahim, George M.
dc.contributor.authorKola, Olivia
dc.contributor.authorTseng, Chi-Hong
dc.contributor.authorChen, Jia-Shu
dc.contributor.authorLin, Kao-Min
dc.contributor.authorCai, Li-Xin
dc.contributor.authorLiu, Qing-Zhu
dc.contributor.authorLin, Jiu-Luan
dc.contributor.authorZhou, Wen-Jing
dc.contributor.authorMathern, Gary W.
dc.contributor.authorSmyth, Matthew D.
dc.contributor.authorO'Neill, Brent R.
dc.contributor.authorDudley, Roy
dc.contributor.authorRagheb, John
dc.contributor.authorBhatia, Sanjiv
dc.contributor.authorDelev, Daniel
dc.contributor.authorRamantani, Georgia
dc.contributor.authorZentner, Josef
dc.contributor.authorWang, Anthony C.
dc.contributor.authorDorfer, Christian
dc.contributor.authorFeucht, Martha
dc.contributor.authorCzech, Thomas
dc.contributor.authorBollo, Robert J.
dc.contributor.authorIssabekov, Galymzhan
dc.contributor.authorZhu, Hongwei
dc.contributor.authorConnolly, Mary
dc.contributor.authorSteinbok, Paul
dc.contributor.authorZhang, Jian-Guo
dc.contributor.authorZhang, Kai
dc.contributor.authorHidalgo, Eveline Teresa
dc.contributor.authorWeiner, Howard L.
dc.contributor.authorWong-Kisiel, Lily
dc.contributor.authorLapalme-Remis, Samuel
dc.contributor.authorTripathi, Manjari
dc.contributor.authorSarat Chandra, Poodipedi
dc.contributor.authorHader, Walter
dc.contributor.authorWang, Feng-Peng
dc.contributor.authorYao, Yi
dc.contributor.authorChampagne, Pierre Olivier
dc.contributor.authorBrunette-Clement, Tristan
dc.contributor.authorGuo, Qiang
dc.contributor.authorLi, Shao-Chun
dc.contributor.authorBudke, Marcelo
dc.contributor.authorPerez-Jimenez, Maria Angeles
dc.contributor.authorRaftopoulos, Christian
dc.contributor.authorFinet, Patrice
dc.contributor.authorMichel, Pauline
dc.contributor.authorSchaller, Karl
dc.contributor.authorStienen, Martin N.
dc.contributor.authorBaro, Valentina
dc.contributor.authorCantillano Malone, Christian
dc.contributor.authorPociecha, Juan
dc.contributor.authorChamorro, Noelia
dc.contributor.authorMuro, Valeria L.
dc.contributor.authorvon Lehe, Marec
dc.contributor.authorVieker, Silvia
dc.contributor.authorOluigbo, Chima
dc.contributor.authorGaillard, William D.
dc.contributor.authorAl Khateeb, Mashael
dc.contributor.authorAl Otaibi, Faisal
dc.contributor.authorKrayenbuhl, Niklaus
dc.contributor.authorBolton, Jeffrey
dc.contributor.authorPearl, Phillip L.
dc.contributor.authorFallah, Aria
dc.date.accessioned2025-01-20T17:11:06Z
dc.date.available2025-01-20T17:11:06Z
dc.date.issued2024
dc.description.abstractObjectivesAlthough hemispheric surgeries are among the most effective procedures for drug-resistant epilepsy (DRE) in the pediatric population, there is a large variability in seizure outcomes at the group level. A recently developed HOPS score provides individualized estimation of likelihood of seizure freedom to complement clinical judgement. The objective of this study was to develop a freely accessible online calculator that accurately predicts the probability of seizure freedom for any patient at 1-, 2-, and 5-years post-hemispherectomy.MethodsRetrospective data of all pediatric patients with DRE and seizure outcome data from the original Hemispherectomy Outcome Prediction Scale (HOPS) study were included. The primary outcome of interest was time-to-seizure recurrence. A multivariate Cox proportional-hazards regression model was developed to predict the likelihood of post-hemispheric surgery seizure freedom at three time points (1-, 2- and 5- years) based on a combination of variables identified by clinical judgment and inferential statistics predictive of the primary outcome. The final model from this study was encoded in a publicly accessible online calculator on the International Network for Epilepsy Surgery and Treatment (iNEST) website ().ResultsThe selected variables for inclusion in the final model included the five original HOPS variables (age at seizure onset, etiologic substrate, seizure semiology, prior non-hemispheric resective surgery, and contralateral fluorodeoxyglucose-positron emission tomography [FDG-PET] hypometabolism) and three additional variables (age at surgery, history of infantile spasms, and magnetic resonance imaging [MRI] lesion). Predictors of shorter time-to-seizure recurrence included younger age at seizure onset, prior resective surgery, generalized seizure semiology, FDG-PET hypometabolism contralateral to the side of surgery, contralateral MRI lesion, non-lesional MRI, non-stroke etiologies, and a history of infantile spasms. The area under the curve (AUC) of the final model was 73.0%.SignificanceOnline calculators are useful, cost-free tools that can assist physicians in risk estimation and inform joint decision-making processes with patients and families, potentially leading to greater satisfaction. Although the HOPS data was validated in the original analysis, the authors encourage external validation of this new calculator.
dc.description.funderNone.
dc.fuente.origenWOS
dc.identifier.doi10.1111/epi.17689
dc.identifier.eissn1528-1167
dc.identifier.issn0013-9580
dc.identifier.urihttps://doi.org/10.1111/epi.17689
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91159
dc.identifier.wosidWOS:001106757200001
dc.issue.numero1
dc.language.isoen
dc.pagina.final56
dc.pagina.inicio46
dc.revistaEpilepsia
dc.rightsacceso restringido
dc.subjecthemispherectomy
dc.subjecthemispherotomy
dc.subjectonline calculator
dc.subjectseizure outcomes
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDevelopment of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)
dc.typeartículo
dc.volumen65
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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