Childhood obesity: a risk factor for non-alcoholic fatty liver disease in adolescence

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dc.contributor.advisorGana Ansaldo, Juan Cristóbal
dc.contributor.advisorAlberti, Gigliola
dc.contributor.authorCuzmar Benítez, Valeria
dc.contributor.otherPontificia Universidad Católica de Chile. Facultad de Medicina
dc.date2022-12-31
dc.date.accessioned2020-11-18T12:36:04Z
dc.date.available2020-11-18T12:36:04Z
dc.date.issued2019
dc.descriptionTesis (Magíster en Nutrición)--Pontificia Universidad Católica de Chile, 2019
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD), defined as fat accumulation >5% in hepatocytes, may progress to fibrosis or cirrhosis later in life. NAFLD prevalence in adolescents has increased significantly in direct relation with obesity prevalence. Objective: To identify anthropometric variables during the first 10 years of life associated to the risk of developing NAFLD in adolescence. Methods: Longitudinal cohort study 'Growth and Obesity Chilean Cohort Study' (GOCS) consisting of 513 children born in 2002-2003, with yearly anthropometric data collected over a 10 year period. The presence of intra-hepatic fat in the livers of subjects 14-16 years of age was determined using abdominal ultrasound. In addition, elastography was performed on all participants with ultrasound evidence of NAFLD. Results: 9.7% of the participants presented findings compatible with NAFLD. After 2 years of age, obesity significantly and progressively increased the probability of NAFLD occurrence in adolescence. Obesity at 5 years of age was associated with the highest OR for NAFLD, reaching values of 8.91 (95% CI 3.03-16.11). Among participants with NAFLD, those with altered liver elasticity (≥7 Kpa) had greater weight, BMI z-score, waist and hip circumference and altered liver enzymes (p<0.05). Conclusion: The risk of developing NAFLD in adolescence increases progressively with early obesity starting at age 2 years.
dc.fechaingreso.objetodigital2020-11-18
dc.format.extent21 páginas
dc.fuente.origenAutoarchivo
dc.identifier.doi10.7764/tesisUC/MED/48393
dc.identifier.urihttps://doi.org/10.7764/tesisUC/MED/48393
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/48393
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherObesidad - En lactancia y niñezes_ES
dc.subject.otherEnfermedad del hígado graso no alcohólicoes_ES
dc.titleChildhood obesity: a risk factor for non-alcoholic fatty liver disease in adolescencees_ES
dc.typetesis de maestría
sipa.codpersvinculados8726
sipa.codpersvinculados167316
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