Pharmacokinetics of ketorolac in children after abdominal surgery

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dc.contributor.authorGonzalezMartin, G
dc.contributor.authorMaggio, L
dc.contributor.authorGonzalezSotomayor, J
dc.contributor.authorZuniga, S
dc.date.accessioned2024-01-10T13:52:01Z
dc.date.available2024-01-10T13:52:01Z
dc.date.issued1997
dc.description.abstractThe pharmacokinetics of 2 doses of intravenous ketorolac (0.5 and 0.9 mg x kg(-1)) were studied in 14 children (age 2 - 8 years). A single dose of the drug was injected into the dorsum vein of one hand. Blood samples were collected at regular time intervals for 6 hours. Serum ketorolac concentrations were assayed using a high pressure liquid chromatography method. Pharmacokinetic values were estimated by a nonlinear computer program. The distribution volume (Vd(area)), the total clearance (Cl-total), and elimination half-life (t(1/2 beta)) were similar in both groups of children who either received 0.5 or 0.9 mg x kg(-1) of ketorolac. The estimated geometric mean Vd(area), Cl-total, and t(1/2 beta) ratios (95% CI in parentheses) for 0.9 mg x kg(-1): 0.5 mg x kg(-1) were 1.24 (0.82, 1.50), 1.14 (0.88, 1.23), and 1.083 (0.40, 1.81), respectively. The pharmacokinetic parameters found in this study are different from those found by other authors in adult subjects.
dc.fechaingreso.objetodigital2024-06-14
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.issn0946-1965
dc.identifier.pubmedidMEDLINE:9112137
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79639
dc.identifier.wosidWOS:A1997WT57800005
dc.information.autorucQuímica;González G;S/I;98524
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final163
dc.pagina.inicio160
dc.publisherDUSTRI-VERLAG DR KARL FEISTLE
dc.revistaINTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
dc.rightsacceso restringido
dc.subjectketorolac tromethamine
dc.subjectpharmacokinetics
dc.subjectketorolac in children
dc.subjectpostoperative pain
dc.subjectSTATISTICAL-ANALYSIS
dc.subjectMORPHINE KINETICS
dc.subjectTROMETHAMINE
dc.subjectALFENTANIL
dc.subjectMETABOLISM
dc.subjectANALGESIA
dc.subjectINFANTS
dc.subjectHUMANS
dc.subjectPAIN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePharmacokinetics of ketorolac in children after abdominal surgery
dc.typeartículo
dc.volumen35
sipa.codpersvinculados98524
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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