A possible association between primary aldosteronism and a lower beta-cell function

Simple item page
dc.contributor.authorMosso, Lorena M.
dc.contributor.authorCarvajal, Cristian A.
dc.contributor.authorMaiz, Alberto
dc.contributor.authorOrtiz, Eugenia H.
dc.contributor.authorCastillo, Carmen R.
dc.contributor.authorArtigas, Rocio A.
dc.contributor.authorFardella, Carlos E.
dc.date.accessioned2024-01-10T13:11:11Z
dc.date.available2024-01-10T13:11:11Z
dc.date.issued2007
dc.description.abstractObjective Primary aldosteronism ( PA) is the most common secondary cause of hypertension and recently has been implicated as a cause of impaired glucose tolerance. We investigated the glucose insulin sensitivity and insulin secretion in patients with idiopathic primary aldosteronism.
dc.description.abstractDesign Thirty PA patients and 60 essential hypertensive ( EH) patients as controls were included, matched ( 1 : 2) by their body mass index ( BMI) ( 29.9 +/- 4.3 versus 29.8 +/- 5.8 m/ kg 2), age ( 53.7 +/- 9.4 versus 59.9 +/- 8.6 years old) and gender ( male/ female: 8/ 22 versus 17/ 43). In all patients, we measured insulin, total cholesterol, triglycerides, C- peptide and fasting glucose levels. Homeostasis model assessment for insulin resistance ( HOMA- IR) and HOMA of pancreatic beta- cell function ( HOMA- beta F) indexes were calculated. We also evaluated the response to spironolactone in 19 PA patients.
dc.description.abstractResults PA patients had higher levels of glucose ( 5.2 +/- 0.7 versus 4.9 +/- 0.7 mmol/ l; P=0.017). Insulin levels ( 10.7 +/- 6.5 versus 11.5 +/- 5.8 uUI/ ml, P=0.525) and HOMA- IR ( 2.51 +/- 1.59 versus 2.45 +/- 1.29 uUI/ ml x mmol/ l, PU0.854) were similar in both groups. HOMA- bF index ( 138.9 +/- 89.8 versus 179.8 +/- 100.2%, P=0.049) and C- peptide ( 0.83 +/- 0.63 versus 1.56 +/- 0.84 ng/ dl, P=0.0001) were lower in PA patients. Potassium was normal inboth groups. Negative correlations between serum aldosterone/ plasma renin activity ( SA/ PRA) ratio and HOMA- beta F, and between C- peptide and SA levels were found in all patients. After the spironolactone treatment, we found an increase of C- peptide and insulin levels without changes in HOMA- IR or HOMA- beta F.
dc.description.abstractConclusion Our results showed differences in glucose metabolism between PA patients and those with hypertension suggesting that these findings could probably be determined by a lower beta- cell function influenced by aldosterone. These findings highlight the importance of aldosterone in glucose metabolism.
dc.fechaingreso.objetodigital2024-05-22
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/HJH.0b013e3282861fa4
dc.identifier.eissn1473-5598
dc.identifier.issn0263-6352
dc.identifier.pubmedidMEDLINE:17885557
dc.identifier.urihttps://doi.org/10.1097/HJH.0b013e3282861fa4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78010
dc.identifier.wosidWOS:000249780000024
dc.information.autorucMedicina;Carvajal C;S/I;8586
dc.information.autorucMedicina;Fardella C;S/I;66235
dc.information.autorucMedicina;Maiz A;S/I;23935
dc.information.autorucMedicina;Mosso L;S/I;88201
dc.issue.numero10
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final2130
dc.pagina.inicio2125
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaJOURNAL OF HYPERTENSION
dc.rightsacceso restringido
dc.subjectaldosterone
dc.subjectglucose metabolism
dc.subjectprimary aldosteronism
dc.subjectHOMEOSTASIS MODEL ASSESSMENT
dc.subjectINSULIN SENSITIVITY
dc.subjectPLASMA-ALDOSTERONE
dc.subjectRECEPTOR BLOCKERS
dc.subjectPOTASSIUM
dc.subjectGLUCOSE
dc.subjectGLUCOCORTICOIDS
dc.subjectPREVALENCE
dc.subjectRESISTANCE
dc.subjectINHIBITORS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA possible association between primary aldosteronism and a lower beta-cell function
dc.typeartículo
dc.volumen25
sipa.codpersvinculados8586
sipa.codpersvinculados66235
sipa.codpersvinculados23935
sipa.codpersvinculados88201
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
A possible association between primary aldosteronism and a lower beta-cell function.pdf
Size:
3.5 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas