Association of Novel Genetic Loci With Circulating Fibrinogen Levels A Genome-Wide Association Study in 6 Population-Based Cohorts

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dc.contributor.authorDehghan, Abbas
dc.contributor.authorYang, Qiong
dc.contributor.authorPeters, Annette
dc.contributor.authorBasu, Saonli
dc.contributor.authorBis, Joshua C.
dc.contributor.authorRudnicka, Alicja R.
dc.contributor.authorKavousi, Maryam
dc.contributor.authorChen, Ming Huei
dc.contributor.authorBaumert, Jens
dc.contributor.authorLowe, Gordon D. O.
dc.contributor.authorMcKnight, Barbara
dc.contributor.authorTang, Weihong
dc.contributor.authorde Maat, Moniek
dc.contributor.authorLarson, Martin G.
dc.contributor.authorEyhermendy, Susana
dc.contributor.authorMcArdle, Wendy L.
dc.contributor.authorLumley, Thomas
dc.contributor.authorPankow, James S.
dc.contributor.authorHofman, Albert
dc.contributor.authorMassaro, Joseph M.
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorKolz, Melanie
dc.contributor.authorTaylor, Kent D.
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorKathiresan, Sekar
dc.contributor.authorIllig, Thomas
dc.contributor.authorAulchenko, Yurii S.
dc.contributor.authorVolcik, Kelly A.
dc.contributor.authorJohnson, Andrew D.
dc.contributor.authorUitterlinden, Andre G.
dc.contributor.authorTofler, Geoffrey H.
dc.contributor.authorGieger, Christian
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorCouper, David J.
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorKoenig, Wolfgang
dc.contributor.authorO'Donnell, Christopher J.
dc.contributor.authorWitteman, Jacqueline C.
dc.contributor.authorStrachan, David P.
dc.contributor.authorSmith, Nicholas L.
dc.contributor.authorFolsom, Aaron R.
dc.contributor.authorWellcome Trust Case Control Consor
dc.date.accessioned2024-01-10T12:37:42Z
dc.date.available2024-01-10T12:37:42Z
dc.date.issued2009
dc.description.abstractBackground: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. Methods and Results: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P<5.0×10-8). These included a single-nucleotide polymorphism located in the fibrinogen β chain (FGB) gene and 3 single-nucleotide polymorphisms representing newly identified loci. The high-signal single-nucleotide polymorphisms were rs1800789 in exon 7 of FGB (P=1.8×10-30), rs2522056 downstream from the interferon regulatory factor 1 (IRF1) gene (P=1.3×10-15), rs511154 within intron 1 of the propionyl coenzyme A carboxylase (PCCB) gene (P=5.9×10-10), and rs1539019 on the NLR family pyrin domain containing 3 isoforms (NLRP3) gene (P=1.04×10-8). Conclusions: Our findings highlight biological pathways that may be important in regulation of inflammation underlying cardiovascular disease. © 2009 American Heart Association, Inc.
dc.description.funderErasmus Medical Center and Erasmus University Rotterdam
dc.description.funderNetherlands Organization for Scientific Research
dc.description.funderNetherlands Organization for Health Research and Development
dc.description.funderResearch Institute for Diseases in the Elderly
dc.description.funderNetherlands Heart Foundation
dc.description.funderMinistry of Education, Culture and Science
dc.description.funderMinistry of Health Welfare and Sports
dc.description.funderEuropean Commission
dc.description.funderMunicipality of Rotterdam
dc.description.funderNetherlands Genomics Initiative/Netherlands Organization for Scientific Research
dc.description.funderNational Heart, Lung, and Blood Institute
dc.description.funderAffymetrix Inc
dc.description.funderNational Human Genome Research Institute
dc.description.funderNational Institutes of Health
dc.description.funderNIH Roadmap for Medical Research
dc.description.funderNational Center for Research Rosources
dc.description.funderNational Institute of Diabetes and Digestive and Kidney Diseases
dc.description.funderHelmholtz Zentrum Munchen
dc.description.funderGerman Research Center for Environmental Health (Neuherberg, Germany)
dc.description.funderGerman Federal Ministry of Education and Research
dc.description.funderGerman National Genome Research Network
dc.description.funderMedical Research Council
dc.description.funderChief Scientist Office
dc.description.funderDIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS
dc.description.funderNATIONAL CENTER FOR RESEARCH RESOURCES
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.description.funderNATIONAL HUMAN GENOME RESEARCH INSTITUTE
dc.description.funderNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
dc.fechaingreso.objetodigital2024-05-20
dc.format.extent17 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1161/CIRCGENETICS.108.825224
dc.identifier.eissn1942-3268
dc.identifier.issn1942-325X
dc.identifier.pubmedidMEDLINE:20031576
dc.identifier.urihttps://doi.org/10.1161/CIRCGENETICS.108.825224
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76905
dc.identifier.wosidWOS:000275979200005
dc.information.autorucMatemática;Eyheramendy S, et al;S/I;82611
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaCIRCULATION-CARDIOVASCULAR GENETICS
dc.rightsacceso restringido
dc.subjectgenome-wide association study
dc.subjectfibrinogen
dc.subjectgenes
dc.subjectmeta-analysis
dc.subjectINFLAMMATORY-BOWEL-DISEASE
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectVENOUS THROMBOSIS
dc.subjectPLASMA-FIBRINOGEN
dc.subjectFRAMINGHAM
dc.subjectDESIGN
dc.subjectRISK
dc.subjectEXPRESSION
dc.subjectHEART
dc.subjectOBJECTIVES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation of Novel Genetic Loci With Circulating Fibrinogen Levels A Genome-Wide Association Study in 6 Population-Based Cohorts
dc.typeartículo
dc.volumen2
sipa.codpersvinculados82611
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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