Alcohol impairshippocampal function:FromNMDAreceptorsynaptic transmissiontomitochondrial function

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dc.catalogadorjlo
dc.contributor.authorMira, Rodrigo G.
dc.contributor.authorTapia Rojas, Cheril
dc.contributor.authorPérez, María José
dc.contributor.authorJara, Claudia
dc.contributor.authorVergara, Erick H.
dc.contributor.authorQuintanilla, Rodrigo A.
dc.contributor.authorCerpa Nebott, Waldo Francisco
dc.date.accessioned2024-01-29T17:48:28Z
dc.date.available2024-01-29T17:48:28Z
dc.date.issued2019
dc.description.abstractMany studies have reported that alcohol produces harmful effects on several brain structures, including the hippocampus, in both rodents and humans. The hippocampus is one of the most studied areas of the brain due to its function in learning and memory, and a lot of evidence suggests that hippocampal failure is responsible for the cognitive loss present in individuals with recurrent alcohol consumption. Mitochondria are organelles that generate the energy needed for the brain to maintain neuronal communication, and their functional failure is considered a mediator of the synaptic dysfunction induced by alcohol. In this review, we discuss the mechanisms of how alcohol exposure affects neuronal communication through the impairment of glutamate receptor (NMDAR) activity, neuroinflammatory events and oxidative damage observed after alcohol exposure, all processes under the umbrella of mitochondrial function. Finally, we discuss the direct role of mitochondrial dysfunction mediating cognitive and memory decline produced by alcohol exposure and their consequences associated with neurodegeneration.
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1016/j.drugalcdep.2019.107628
dc.identifier.issn0376-8716
dc.identifier.urihttps://doi.org/10.1016/j.drugalcdep.2019.107628
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81013
dc.information.autorucFacultad de Ciencias Biológicas; Mira Guzmán, Rodrigo Andrés; S/I; 215451
dc.information.autorucFacultad de Ciencias Biológicas; Cerpa Nebott, Waldo Francisco; 0000-0001-7344-0144; 16584
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final10
dc.pagina.inicio1
dc.revistaDrug and Alcohol Dependence
dc.rightsacceso restringido
dc.subjectAlcohol
dc.subjectSynapses
dc.subjectGlutamate
dc.subjectMitochondria
dc.subjectOxidative stress
dc.subjectNeurotoxicity
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleAlcohol impairshippocampal function:FromNMDAreceptorsynaptic transmissiontomitochondrial function
dc.typeartículo de revisión
dc.volumen205
sipa.codpersvinculados215451
sipa.codpersvinculados16584
sipa.trazabilidadORCID;2024-01-15
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