Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension.

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dc.catalogadorpau
dc.contributor.authorMuñoz-Durango, Natalia
dc.contributor.authorFuentes, Cristóbal A.
dc.contributor.authorCastillo, Andrés E.
dc.contributor.authorGonzález-Gómez, Luis Martín
dc.contributor.authorVecchiola, Andrea
dc.contributor.authorFardella, Carlos E.
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-03-07T18:57:17Z
dc.date.available2024-03-07T18:57:17Z
dc.date.issued2016
dc.description.abstractArterial hypertension is a common condition worldwide and an important predictor of several complicated diseases. Arterial hypertension can be triggered by many factors, including physiological, genetic, and lifestyle causes. Specifically, molecules of the renin-angiotensin-aldosterone system not only play important roles in the control of blood pressure, but they are also associated with the genesis of arterial hypertension, thus constituting a need for pharmacological interventions. Chronic high pressure generates mechanical damage along the vascular system, heart, and kidneys, which are the principal organs affected in this condition. In addition to mechanical stress, hypertension-induced oxidative stress, chronic inflammation, and the activation of reparative mechanisms lead to end-organ damage, mainly due to fibrosis. Clinical trials have demonstrated that renin-angiotensin-aldosterone system intervention in hypertensive patients lowers morbidity/mortality and inflammatory marker levels as compared to placebo patients, evidencing that this system controls more than blood pressure. This review emphasizes the detrimental effects that a renin-angiotensin-aldosterone system (RAAS) imbalance has on health considerations above and beyond high blood pressure, such as fibrotic end-organ damage.
dc.fechaingreso.objetodigital2024-05-29
dc.format.extent17 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/ijms17070797
dc.identifier.issn1422-0067
dc.identifier.urihttp://europepmc.org/articles/PMC4964362
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84290
dc.information.autorucEscuela de Medicina; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.issue.numero7
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaInternational Journal of Molecular Sciences,
dc.rightsacceso abierto
dc.titleRole of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension.
dc.typeartículo
dc.volumen17
sipa.codpersvinculados90610
sipa.trazabilidadORCID;2024-01-15
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