A comparative study of two different methods for the detection of latent tuberculosis in HIV-positive individuals in Chile

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dc.catalogadoryvc
dc.contributor.authorBalcells Marty, María Elvira
dc.contributor.authorPérez Cortes, Carlos Miguel
dc.contributor.authorChanqueo Cornejo, Leonardo Andrés
dc.contributor.authorLasso Barreto, Martin Francisco
dc.contributor.authorVillanueva, Marcela
dc.contributor.authorEspinoza Concha, Mónica Ximena
dc.contributor.authorVillarroel Del Pino, Luis Antonio
dc.contributor.authorGarcía Cañete, Patricia Del Carmen
dc.date.accessioned2023-11-09T19:44:45Z
dc.date.available2023-11-09T19:44:45Z
dc.date.issued2008
dc.description.abstractObjective: To compare the performance of two tests for diagnosing latent tuberculosis (TB) infection in the HIV-positive population in Chile, in order to better identify the subjects who might benefit from TB chemoprophylaxis. Design: This was a cross-sectional study among individuals attending three HIV outpatient clinics in Santiago, tested with a 2-TU purified protein derivative, QuantiFERON ® -TB Gold ‘in-tube’ (QFT-G), and a chest X-ray. Results: A total of 116 subjects were enrolled in the study, having a mean CD4 count of 393 cells/μl (range 100–977). The tuberculin skin text (TST; 5 mm cutoff) and QFT-G results were positive in 10.9% and 14.8% of the individuals, respectively, with moderate agreement between both tests (kappa = 0.59). A history of both known TB exposure (odds ratio (OR) 3.46, 95% confidence interval (CI) 1.02–11.22) and past TB (OR 4.31, 95% CI 1.13–15.5) were associated with a positive QFT-G result. Only past TB was significantly associated with a positive TST result (OR 6.63, 95% CI 1.62–26.3). Among the subjects with TST < 5 mm, 8.2% were positive by QFT-G test. These individuals had a lower mean CD4 cell count than those detected positive by both tests (328 cells/μl and 560 cells/μl, respectively, p = 0.03). Conclusions: In this population of HIV-infected individuals, QFT-G and TST showed an acceptable level of agreement, although QFT-G appears less affected by more advanced immunosuppression.
dc.fechaingreso.objetodigital2023-11-09
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ijid.2008.03.005
dc.identifier.eissn1878-3511
dc.identifier.issn1201-9712
dc.identifier.pubmedidMEDLINE_ID: 18534887
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2008.03.005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75267
dc.identifier.wosidWOS:000261096900018
dc.information.autorucEscuela de Medicina; Balcells Marty, María Elvira; 0000-0002-7223-9665; 7462
dc.information.autorucEscuela de Medicina; Pérez Cortes, Carlos Miguel; S/I; 66650
dc.information.autorucEscuela de Medicina; Chanqueo Cornejo, Leonardo Andrés; S/I; 146071
dc.information.autorucEscuela de Medicina; Lasso Barreto, Martin Francisco; S/I; 1002080
dc.information.autorucEscuela de Medicina; Espinoza Concha, Mónica Ximena; S/I; 1009701
dc.information.autorucEscuela de Medicina; Villarroel Del Pino, Luis Antonio; 0000-0001-9603-937X; 77182
dc.information.autorucEscuela de Medicina; García Cañete, Patricia Del Carmen; 0000-0002-5983-2392; 73909
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final652
dc.pagina.inicio645
dc.publisherElsevier Ltd
dc.relation.isformatofAnnual Meeting of the Infectious Diseases Society of America (45th : 2007 : San Diego, CA)
dc.revistaInternational Journal of Infectious Diseases
dc.rightsacceso restringido
dc.subjectTuberculosis
dc.subjectLatent tuberculosis
dc.subjectDiagnosis
dc.subjectTuberculin skin test
dc.subjectHIV
dc.subjectBacille Calmette Guerin
dc.subjectInterferon Gamma Assay
dc.subjectMycobacterium Tuberculosis
dc.subjectVaccination
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA comparative study of two different methods for the detection of latent tuberculosis in HIV-positive individuals in Chile
dc.typeartículo
dc.volumen12
sipa.codpersvinculados7462
sipa.codpersvinculados66650
sipa.codpersvinculados146071
sipa.codpersvinculados1002080
sipa.codpersvinculados1009701
sipa.codpersvinculados77182
sipa.codpersvinculados73909
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