Could BCG vaccination induce protective trained immunity for SARS-CoV-2?

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dc.contributor.authorCovián, Camila
dc.contributor.authorRetamal Díaz, Angello Ricardo
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.date.accessioned2020-06-17T15:32:43Z
dc.date.available2020-06-17T15:32:43Z
dc.date.issued2020
dc.description.abstractTrained immunity is a type of non-specific memory-like immune response induced by some pathogens and vaccines, such as BCG, which can confer antigen-independent protection against a wide variety of pathogens. The BCG vaccine has been extensively used to protect against tuberculosis for almost a 100 years. Interestingly, this vaccine reduces children's mortality caused by infections unrelated to Mycobacterium tuberculosis infection, a phenomenon thought to be due to the induction of trained immunity. The SARS-CoV-2 pandemic has infected, as of April 22, 2020, 2,623,231 people globally, causing a major public health problem worldwide. Currently, no vaccine or treatment is available to control this pandemic. We analyzed the number of positive cases and deaths in different countries and correlated them with the inclusion of BCG vaccination at birth in their national vaccination programs. Interestingly, those countries where BCG vaccination is given at birth have shown a lower contagion rate and fewer COVID-19-related deaths, suggesting that this vaccine may induce trained immunity that could confer some protection for SARS-CoV-2.
dc.identifier.doi10.3389/fimmu.2020.00970
dc.identifier.issn1664-3224
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/29403
dc.identifier.urihttps://doi.org/10.3389/fimmu.2020.00970
dc.issue.numeroNo. 970
dc.pagina.final7
dc.pagina.inicio1
dc.relation.isformatofFrontiers in Immunology, vol. 11, no. 970 (2020), 7 p.
dc.rightsacceso abierto
dc.subjectSARS-CoV-2es_ES
dc.subjectCOVID-19es_ES
dc.subjectBCGes_ES
dc.subjectInnate immunityes_ES
dc.subjectTrained immunityes_ES
dc.subjectVaccinees_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleCould BCG vaccination induce protective trained immunity for SARS-CoV-2?es_ES
dc.typeartículo
dc.volumenVol. 11
sipa.codpersvinculados225150
sipa.codpersvinculados113541
sipa.codpersvinculados90610
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