Induction of Tolerogenic Dendritic Cells by NF-κB Blockade and Fcγ Receptor Modulation

Simple item page
dc.catalogadorpau
dc.contributor.authorCarreño, Leandro J.
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-03-07T18:57:18Z
dc.date.available2024-03-07T18:57:18Z
dc.date.issued2011
dc.description.abstractAutoimmune diseases develop as a result of an unbalanced adaptive immunity that targets self-antigens and causes destruction of healthy host tissues. Maintenance of peripheral immune tolerance to self- antigens is mainly mediated by dendritic cells (DCs), professional antigen-presenting cells that modulate the activation of T cells. Due to their key role as regulators of adaptive immunity, identification of means of enhancing DC tolerogenic capacity and therapeutic potential is a priority goal to reduce autoimmune disease burden in an antigen-specific manner. Our findings suggest novel approaches to enhance DC capacity to induce self-tolerance and reduce the severity of autoimmune disorders. Specifically, we have shown, both in vitro and in vivo, that NF-κB blockade on DCs by andrographolide or rosiglitazone can significantly enhance the tolerogenic capacity of DCs. Furthermore, we have observed that expression ratio of the activating FcγRIII or the inhibitory FcγRIIb is determinant for the tolerogenic potential of DCs. In this chapter, we describe the procedures to produce tolerogenic DCs and explain the potential therapeutic use of two NF-κB inhibitors for the treatment of autoimmune disease models, such as experimental autoimmune encephalomyelitis (EAE) and systemic lupus erythematosus (SLE) in mice. Therefore, our studies support the notion that FcγRs and NF-κB can be considered as pharmacological targets to increase the capacity of DCs to induce or restore self-tolerance and decrease inflammatory damage to self-tissues.
dc.fuente.origenORCID
dc.identifier.doi10.1007/978-1-60761-869-0_22
dc.identifier.urihttps://doi.org/10.1007/978-1-60761-869-0_22
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84295
dc.information.autorucEscuela de Medicina; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.language.isoen
dc.nota.accesoContenido parcial
dc.relation.ispartofSuppression and Regulation of Immune Responses. Methods in Molecular Biology, vol 677. Humana Press, Totowa, NJ, 2010, XVIII, 473 páginas.
dc.rightsacceso restringido
dc.titleInduction of Tolerogenic Dendritic Cells by NF-κB Blockade and Fcγ Receptor Modulation
dc.typecapítulo de libro
sipa.codpersvinculados90610
sipa.trazabilidadORCID;2024-01-15
Files
Collections
Capítulos de libros