Differences in clinical aspects of human cystic echinococcosis caused by Echinococcus granulosus sensu stricto and the G6 genotype in Neuquén, Argentina

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dc.catalogadorpau
dc.contributor.authorDebiaggi, María Florencia
dc.contributor.authorÁlvarez Rojas, Cristián Andrés
dc.contributor.authorLazzarini, Lorena Evelina
dc.contributor.authorCalfunao, Daniel
dc.contributor.authorTitanti, Paola
dc.contributor.authorCalanni, Liliana
dc.contributor.authorIacono, Marisa
dc.contributor.authorSoriano, Silvia Viviana
dc.contributor.authorDeplazes, Peter
dc.contributor.authorPierangeli, Nora Beatriz
dc.date.accessioned2023-07-13T19:48:11Z
dc.date.available2023-07-13T19:48:11Z
dc.date.issued2023
dc.description.abstractMost human cystic echinococcosis (CE) cases worldwide are attributed to Echinococcus granulosus sensu stricto (s.s), followed by the G6 and G7 genotypes. While E. granulosus s.s. has a cosmopolitan distribution, the G6 genotype is restricted to areas where camels and goats are present. Goats are the primary livestock in the Neuquén province in Argentina where the G6 genotype has been reported to be responsible for a significant percentage of CE human cysts genotyped. In the present study, we genotyped 124 Echinococcus cysts infecting 90 CE-confirmed patients. Echinococcus granulosus s.s. was identified in 51 patients (56.7%) with 81 cysts and the G6 genotype in 39 patients (43.3%) harbouring 43 cysts. Most CE cases ≤18 years were male suggesting pastoral work could be a risk factor for the infection. Echinococcus granulosus s.s. was significantly found more frequently in the liver (32/51 patients) and the G6 genotype in the lungs and extrahepatic localizations (27/39). The patients infected with E. granulosus s.s., presented up to 6 cysts while patients infected with G6 presented a maximum of 2. The diameter of lung cysts attributed to E. granulosus s.s. was significantly larger compared to lung cysts from G6. Following the WHO ultrasound classification of liver cysts, we observed inactive cysts in 55.6% of G6 cysts and only 15.3% of E. granulosus s.s cysts. In conclusion, we provide evidence of differences in clinical aspects of CE caused by E. granulosus s.s. and the G6 genotype of E. granulosus s.l. complex infecting humans.
dc.fechaingreso.objetodigital2023-07-12
dc.format.extent7 páginas
dc.fuente.origenCambridge University Press
dc.identifier.doi10.1017/S0031182023000264
dc.identifier.issn0031-1820
dc.identifier.urihttps://doi.org/10.1017/S0031182023000264
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74170
dc.information.autorucEscuela de Medicina Veterinaria; Álvarez Rojas, Cristián Andrés; 0000-0002-8069-7607; 1225028
dc.issue.numero7
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final605
dc.pagina.inicio599
dc.revistaParasitology
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0)
dc.subjectClinical aspects
dc.subjectCox1
dc.subjectEchinococcus granulosus sensu stricto
dc.subjectEchinococcus granulosus
dc.subjectGenotype G6
dc.subjectGenotypes
dc.subjectHuman cystic echinococcosis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleDifferences in clinical aspects of human cystic echinococcosis caused by Echinococcus granulosus sensu stricto and the G6 genotype in Neuquén, Argentinaes_ES
dc.typeartículo
dc.volumen150
sipa.codpersvinculados1225028
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