Multiple sclerosis and related disorders: Short report peripheral vascular events in a real-world cohort of multiple sclerosis patients using Fingolimod

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dc.catalogadoraba
dc.contributor.authorPelayo, Carolina
dc.contributor.authorCiampi Díaz, Ethel Leslie
dc.contributor.authorUribe San Martín, Reinaldo
dc.contributor.authorSoler León, Bernardita María
dc.contributor.authorReyes, Ana
dc.contributor.authorVergara, Elizabeth
dc.contributor.authorCárcamo Rodríguez, Claudia Andrea
dc.date.accessioned2024-01-17T19:36:04Z
dc.date.available2024-01-17T19:36:04Z
dc.date.issued2020
dc.description.abstractBackground: Fingolimod is a high-efficacy disease-modifying therapy for multiple sclerosis (MS) and was the first oral treatment approved for the disease. Adverse events include bradyarrhythmia, hypertension, macular oedema and increased risk of infections, mainly due to its main mechanism of action, the non-selective modulation of sphingosine-1-phosphate receptor.", "Methods and Results: We report the baseline characteristics, effectiveness outcomes and adverse events of a prospective cohort of 177 patients with a median treatment duration of 24 months, in which four patients (2.3%) presented with otherwise non-provoked peripheral vascular events (PVE).", "Conclusions: Further studies are still needed to evaluate the frequency and severity of PVE in fingolimod patients.
dc.fechaingreso.objetodigital2024-01-19
dc.format.extent6 páginas
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1016/j.msard.2020.102411
dc.identifier.eissn2211-0356
dc.identifier.issn2211-0348
dc.identifier.urihttps://doi.org/10.1016/j.msard.2020.102411
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80566
dc.identifier.wosidWOS:000582230900057
dc.information.autorucMedicina;Ana Reyes;S/I;1013047
dc.information.autorucMedicina;Bernardita Soler;S/I;189547
dc.information.autorucMedicina;Claudia Cárcamo;S/I;562
dc.information.autorucMedicina;Elizabeth Vergara;S/I;82229
dc.information.autorucMedicina;Ethel Ciampi;S/I;132794
dc.information.autorucMedicina;Reinaldo Uribe San Martin;S/I;127201
dc.information.autorucEscuela de Medicina; Ciampi Díaz, Ethel Leslie; 0000-0002-7330-5433; 132794
dc.information.autorucEscuela de Medicina; Uribe San Martín, Reinaldo; 0000-0002-3422-7962; 127201
dc.information.autorucEscuela de Medicina; Soler León, Bernardita María; 0000-0002-8143-4497; 189547
dc.information.autorucEscuela de Medicina; Cárcamo Rodríguez, Claudia Andrea; 0000-0002-9430-216X; 562
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final6
dc.pagina.inicio1
dc.revistaMultiple Sclerosis and Related Disorders
dc.rightsacceso restringido
dc.subjectMultiple sclerosisDisease-modifying treatment
dc.subjectFingolimod
dc.subjectAdverse events
dc.subjectThrombosis
dc.subjectPeripheral vascular events
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMultiple sclerosis and related disorders: Short report peripheral vascular events in a real-world cohort of multiple sclerosis patients using Fingolimod
dc.typeartículo
dc.volumen45
sipa.codpersvinculados1013047
sipa.codpersvinculados189547
sipa.codpersvinculados562
sipa.codpersvinculados82229
sipa.codpersvinculados132794
sipa.codpersvinculados127201
sipa.indexWoS
sipa.indexScopus
sipa.trazabilidadORCID;2024-01-08
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