Adenosine A(2B) receptor mediates an increase on VEGF-A production in rat kidney glomeruli

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dc.contributor.authorValladares, D.
dc.contributor.authorQuezada, C.
dc.contributor.authorMontecinos, P.
dc.contributor.authorYanez, Aj.
dc.contributor.authorSobrevia, L.
dc.contributor.authorMartin, R. San
dc.date.accessioned2024-01-10T12:04:07Z
dc.date.available2024-01-10T12:04:07Z
dc.date.issued2008
dc.description.abstractUp-regulation of the glomerular expression and the activity of vascular endothelial growth factor-A (VEGF) have been identified as an early pathogenic event for the progression of diabetic nephropathy. Currently, however the mediators are not yet clearly recognized. In this study we identified all four adenosine receptor (AR) subtypes, i.e. A(1), A(2A), A(2B) and A(3) in isolated rat kidney glomeruli. We localized the expression of A(2B)AR in podocytes, the primary VEGF producing cells. The ex vivo treatment of kidney glomeruli with adenosine or a general AR agonist NECA, increases VEGF protein content. In addition, NECA treatment elicits VEGF release. These effects were blocked by the A(2B)AR selective antagonist MRS1754 supplementation. Furthermore, we showed that A(2B)AR activation was necessary to promote a higher expression of VEGF in kidney glomeruli upon exposure to high D-glucose concentration, a pathogenic condition like those observed in diabetic nephropathy. (c) 2007 Elsevier Inc. All rights reserved.
dc.fechaingreso.objetodigital20-03-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bbrc.2007.11.113
dc.identifier.eissn1090-2104
dc.identifier.issn0006-291X
dc.identifier.pubmedidMEDLINE:18060864
dc.identifier.urihttps://doi.org/10.1016/j.bbrc.2007.11.113
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75691
dc.identifier.wosidWOS:000252392400029
dc.information.autorucMedicina;Sobrevia L;S/I;1002656
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final185
dc.pagina.inicio180
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.revistaBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
dc.rightsacceso restringido
dc.subjectVEGF-A
dc.subjectadenosine receptor
dc.subjectglomerulus
dc.subjecthigh D-glucose
dc.subjectENDOTHELIAL GROWTH-FACTOR
dc.subjectUMBILICAL VEIN ENDOTHELIUM
dc.subjectMOUSE PODOCYTES
dc.subjectDIABETIC-NEPHROPATHY
dc.subjectGENE-EXPRESSION
dc.subjectHYPOXIA
dc.subjectTRANSPORT
dc.subjectGLUCOSE
dc.subjectCELLS
dc.subjectACTIVATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAdenosine A(2B) receptor mediates an increase on VEGF-A production in rat kidney glomeruli
dc.typeartículo
dc.volumen366
sipa.codpersvinculados1002656
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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