Clinical and epidemiological changes of candidemia among adult patients from 2000 to 2013

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dc.contributor.authorSiri, Leonardo
dc.contributor.authorLegarraga, Paulette
dc.contributor.authorGarcia, Patricia
dc.contributor.authorGonzalez, Tamara
dc.contributor.authorRabagliati, Ricardo
dc.date.accessioned2024-01-10T13:46:51Z
dc.date.available2024-01-10T13:46:51Z
dc.date.issued2017
dc.description.abstractBackground: Invasive Candida spp. infections have been described more frequently. Aim: To characterize the epidemiological data of candidemia in recent years. Methods: A retrospective study of adult patients in a University Hospital in Santiago, Chile, with 1 or more documented episodes of candidemia, from January 2000 to December 2013. Results: One hundred and twenty episodes of candidemia were identified in 120 patients, annual incidence of 0.4 cases per 1000 discharges, 53.3% were male patients, 58.3%> 60 years, 77,5% had at least one co-morbidity. Candida albicans was the species most frequently identified 55%, followed by C. glabrata 18.3%, C. tropicalis 11.7% and C. parapsilosis 9.2%. Comparing 2000-2006 vs 2007-2013, increased the frequency of C. parapsilosis among non-albicans and echinocandins prescription. Patients with C. albicans showed higher APACHE-II, more requirement for invasive mechanical ventilation, greater association with CVC, and shorter incubation time compared with non-albicans species. The 30-day mortality was 31.7%. Conclusions: During this 14-years period we observed that C. albicans was the predominant specie and more recently a change among C. non-albicans increasing C. parapsilosis and decreasing C. glabrata 30-days and attributable mortality decreased together with more echinocandins prescription.
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.eissn0717-6341
dc.identifier.issn0716-1018
dc.identifier.pubmedidMEDLINE:28394977
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79207
dc.identifier.wosidWOS:000394923700003
dc.information.autorucMedicina;Garcia P;S/I;73909
dc.information.autorucMedicina;Legarraga P;S/I;3210
dc.information.autorucMedicina;Rabagliati R;S/I;59169
dc.information.autorucMedicina;Siri L ;S/I;142551
dc.issue.numero1
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final26
dc.pagina.inicio19
dc.publisherSOC CHILENA INFECTOLOGIA
dc.revistaREVISTA CHILENA DE INFECTOLOGIA
dc.rightsregistro bibliográfico
dc.subjectCandidemia
dc.subjectcandida
dc.subjectechinocandins
dc.subjectfluconazole
dc.subjectBLOOD CULTURE POSITIVITY
dc.subjectNOSOCOMIAL CANDIDEMIA
dc.subjectINVASIVE CANDIDIASIS
dc.subjectSTREAM INFECTIONS
dc.subjectRISK-FACTOR
dc.subjectMORTALITY
dc.subjectTIME
dc.subjectSUSCEPTIBILITY
dc.subjectIDENTIFICATION
dc.subjectMULTICENTER
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical and epidemiological changes of candidemia among adult patients from 2000 to 2013
dc.typeartículo
dc.volumen34
sipa.codpersvinculados73909
sipa.codpersvinculados3210
sipa.codpersvinculados59169
sipa.codpersvinculados142551
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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