Expression of Transposable Elements in Neural Tissues during <i>Xenopus</i> Development

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dc.contributor.authorFaunes, Fernando
dc.contributor.authorSanchez, Natalia
dc.contributor.authorMoreno, Mauricio
dc.contributor.authorOlivares, Gonzalo H.
dc.contributor.authorLee-Liu, Dasfne
dc.contributor.authorAlmonacid, Leonardo
dc.contributor.authorSlater, Alex W.
dc.contributor.authorNorambuena, Tomas
dc.contributor.authorTaft, Ryan J.
dc.contributor.authorMattick, John S.
dc.contributor.authorMelo, Francisco
dc.contributor.authorLarrain, Juan
dc.date.accessioned2025-01-21T00:01:12Z
dc.date.available2025-01-21T00:01:12Z
dc.date.issued2011
dc.description.abstractTransposable elements comprise a large proportion of animal genomes. Transposons can have detrimental effects on genome stability but also offer positive roles for genome evolution and gene expression regulation. Proper balance of the positive and deleterious effects of transposons is crucial for cell homeostasis and requires a mechanism that tightly regulates their expression. Herein we describe the expression of DNA transposons of the Tc1/mariner superfamily during Xenopus development. Sense and antisense transcripts containing complete Tc1-2_Xt were detected in Xenopus embryos. Both transcripts were found in zygotic stages and were mainly localized in Spemann's organizer and neural tissues. In addition, the Tc1-like elements Eagle, Froggy, Jumpy, Maya, Xeminos and TXr were also expressed in zygotic stages but not oocytes in X. tropicalis. Interestingly, although Tc1-2_Xt transcripts were not detected in Xenopus laevis embryos, transcripts from other two Tc1-like elements (TXr and TXz) presented a similar temporal and spatial pattern during X. laevis development. Deep sequencing analysis of Xenopus tropicalis gastrulae showed that PIWI-interacting RNAs (piRNAs) are specifically derived from several Tc1-like elements. The localized expression of Tc1-like elements in neural tissues suggests that they could play a role during the development of the Xenopus nervous system.
dc.description.funderFONDECYT
dc.fuente.origenWOS
dc.identifier.doi10.1371/journal.pone.0022569
dc.identifier.issn1932-6203
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0022569
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95377
dc.identifier.wosidWOS:000293175100033
dc.issue.numero7
dc.language.isoen
dc.revistaPlos one
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExpression of Transposable Elements in Neural Tissues during <i>Xenopus</i> Development
dc.typeartículo
dc.volumen6
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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