Quantitative Susceptibility Mapping MRI in Deep-Brain Nuclei in First-Episode Psychosis

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dc.catalogadorgjm
dc.contributor.authorGarcía Saborit, Marisleydis
dc.contributor.authorJara Vallejos, Alejandro Antonio
dc.contributor.authorMuñoz Camelo, Néstor Andrés
dc.contributor.authorMilovic, Carlos
dc.contributor.authorTepper, Angeles
dc.contributor.authorAlliende Correa, Luz María
dc.contributor.authorMena, Carlos
dc.contributor.authorIruretagoyena Bruce, Bárbara Arantzazu
dc.contributor.authorRamírez Mahaluf, Juan Pablo
dc.contributor.authorDiaz, Camila
dc.contributor.authorNachar, Rubén
dc.contributor.authorCastaneda, Carmen Paz
dc.contributor.authorGonzalez, Alfonso
dc.contributor.authorUndurraga, Juan
dc.contributor.authorCrossley, Nicolás
dc.contributor.authorTejos Núñez, Cristián Andrés
dc.date.accessioned2024-06-07T15:25:34Z
dc.date.available2024-06-07T15:25:34Z
dc.date.issued2023
dc.description.abstractBackground Psychosis is related to neurochemical changes in deep-brain nuclei, particularly suggesting dopamine dysfunctions. We used an magnetic resonance imaging-based technique called quantitative susceptibility mapping (QSM) to study these regions in psychosis. QSM quantifies magnetic susceptibility in the brain, which is associated with iron concentrations. Since iron is a cofactor in dopamine pathways and co-localizes with inhibitory neurons, differences in QSM could reflect changes in these processes. Methods We scanned 83 patients with first-episode psychosis and 64 healthy subjects. We reassessed 22 patients and 21 control subjects after 3 months. Mean susceptibility was measured in 6 deep-brain nuclei. Using linear mixed models, we analyzed the effect of case-control differences, region, age, gender, volume, framewise displacement (FD), treatment duration, dose, laterality, session, and psychotic symptoms on QSM. Results Patients showed a significant susceptibility reduction in the putamen and globus pallidus externa (GPe). Patients also showed a significant R2* reduction in GPe. Age, gender, FD, session, group, and region are significant predictor variables for QSM. Dose, treatment duration, and volume were not predictor variables of QSM. Conclusions Reduction in QSM and R2* suggests a decreased iron concentration in the GPe of patients. Susceptibility reduction in putamen cannot be associated with iron changes. Since changes observed in putamen and GPe were not associated with symptoms, dose, and treatment duration, we hypothesize that susceptibility may be a trait marker rather than a state marker, but this must be verified with long-term studies.
dc.fuente.origenORCID
dc.identifier.doi10.1093/schbul/sbad041
dc.identifier.eissn1745-1701
dc.identifier.issn0586-7614
dc.identifier.urihttps://doi.org/10.1093/schbul/sbad041
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86628
dc.identifier.wosidWOS:000964210900001
dc.information.autorucEscuela de Ingeniería; García Saborit, Marisleydis; S/I; 1059900
dc.information.autorucFacultad de Matemáticas; Jara Vallejos, Alejandro Antonio; 0000-0002-2282-353X; 127927
dc.information.autorucEscuela de Ingeniería; Muñoz Camelo, Néstor Andrés; S/I; 1059899
dc.information.autorucEscuela de Medicina; Tepper, Angeles; S/I; 1070622
dc.information.autorucEscuela de Psicología; Alliende Correa, Luz María; S/I; 47963
dc.information.autorucEscuela de Medicina; Iruretagoyena Bruce, Bárbara Arantzazu; S/I; 164907
dc.information.autorucEscuela de Medicina; Ramírez Mahaluf, Juan Pablo; 0000-0002-0821-1174; 17132
dc.information.autorucEscuela de Medicina; Crossley, Nicolás; 0000-0002-3060-656X; 11224
dc.information.autorucEscuela de Ingeniería; Tejos Núñez, Cristián Andrés; 0000-0002-8367-155X; 4027
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1363
dc.pagina.inicio1355
dc.revistaSchizophrenia Bulletin
dc.rightsacceso restringido
dc.subjectQSM
dc.subjectMagnetic susceptibility
dc.subjectDopamine
dc.subjectNeuromelanin
dc.subjectR2*rates
dc.titleQuantitative Susceptibility Mapping MRI in Deep-Brain Nuclei in First-Episode Psychosis
dc.typeartículo
dc.volumen49
sipa.codpersvinculados1059900
sipa.codpersvinculados127927
sipa.codpersvinculados1059899
sipa.codpersvinculados1070622
sipa.codpersvinculados47963
sipa.codpersvinculados164907
sipa.codpersvinculados17132
sipa.codpersvinculados11224
sipa.codpersvinculados4027
sipa.trazabilidadORCID;2024-06-03
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