Activation of Melanocortin-4 Receptor by a Synthetic Agonist Inhibits Ethanol-induced Neuroinflammation in Rats

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dc.catalogadorjlo
dc.contributor.authorFlores Bastias, Osvaldo
dc.contributor.authorGomez, Gonzalo I.
dc.contributor.authorOrellana Roca, Juan Andrés
dc.contributor.authorKarahanian, Eduardo
dc.date.accessioned2024-10-14T18:54:52Z
dc.date.available2024-10-14T18:54:52Z
dc.date.issued2019
dc.description.abstractBackground: High ethanol intake induces a neuroinflammatory response resulting in the subsequent maintenance of chronic alcohol consumption. The melanocortin system plays a pivotal role in the modulation of alcohol consumption. Interestingly, it has been shown that the activation of melanocortin-4 receptor (MC4R) in the brain decreases the neuroinflammatory response in models of brain damage other than alcohol consumption, such as LPS-induced neuroinflammation, cerebral ischemia, glutamate excitotoxicity, and spinal cord injury.
dc.description.funderComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
dc.description.funderPrograma de Investigacion Asociativa (PIA) Grant Anillo de Ciencia y Tecnologia
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.2174/1381612825666191216145153
dc.identifier.eissn1873-4286
dc.identifier.issn1381-6128
dc.identifier.pubmedidMEDLINE:31840601
dc.identifier.urihttps://doi.org/10.2174/1381612825666191216145153
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88200
dc.identifier.wosidWOS:000506671300009
dc.information.autorucEscuela de Medicina; Orellana Roca, Juan Andrés; 0000-0003-4076-207X; 126007
dc.issue.numero45
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final4805
dc.pagina.inicio4799
dc.revistaCurrent Pharmaceutical Design
dc.rightsacceso restringido
dc.subjectMelanocortin
dc.subjectAlpha-MSH
dc.subjectAlcohol use disorder
dc.subjectNeuroinflammation
dc.subjectHypothalamus
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleActivation of Melanocortin-4 Receptor by a Synthetic Agonist Inhibits Ethanol-induced Neuroinflammation in Rats
dc.typeartículo
dc.volumen25
sipa.codpersvinculados126007
sipa.trazabilidadWOS;05-06-2021
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