Maternal Plasma Concentration of the Pro-Inflammatory Adipokine Pre-B-Cell-Enhancing Factor (PBEF)/Visfatin Is Elevated In Pregnant Patients with Acute Pyelonephritis

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dc.contributor.authorMazaki Tovi, Shali
dc.contributor.authorVaisbuch, Edi
dc.contributor.authorRomero, Roberto
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorKim, Sun Kwon
dc.contributor.authorNhan Chang, Chia Ling
dc.contributor.authorGomez, Ricardo
dc.contributor.authorYoon, Bo H.
dc.contributor.authorYeo, Lami
dc.contributor.authorMittal, Pooja
dc.contributor.authorOgge, Giovanna
dc.contributor.authorGonzalez, Juan M.
dc.contributor.authorHassan, Sonia S.
dc.date.accessioned2024-01-10T13:14:40Z
dc.date.available2024-01-10T13:14:40Z
dc.date.issued2010
dc.description.abstractProblem
dc.description.abstractVisfatin/pre-B-cell-enhancing factor (PBEF) has been implicated in the regulation of the innate immune system, as well as in glucose metabolism. Specifically, visfatin plays a requisite role in delayed neutrophil apoptosis in patients with sepsis. The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma visfatin concentration in normal weight and overweight/obese patients.
dc.description.abstractMethod of study
dc.description.abstractThis cross-sectional study included the following groups: (1) normal pregnant women (n = 200) and (2) pregnant women with pyelonephritis (n = 40). Maternal plasma visfatin concentrations were determined by ELISA. Non-parametric statistics was used for analyses.
dc.description.abstractResults
dc.description.abstract(1) The median maternal plasma visfatin concentration was significantly higher in patients with pyelonephritis than in those with a normal pregnancy; (2) among overweight/obese pregnant women, those with pyelonephritis had a significantly higher median plasma visfatin concentration than women with a normal pregnancy; and (3) pyelonephritis was independently associated with higher maternal plasma visfatin concentrations after adjustment for maternal age, pre-gestational body mass index, smoking status, gestational age at sampling, and birthweight.
dc.description.abstractConclusion
dc.description.abstractAcute pyelonephritis during pregnancy is associated with a high circulating maternal visfatin concentration. These findings suggest that visfatin/PBEF may play a role in the regulation of the complex and dynamic crosstalk between inflammation and metabolism during pregnancy.
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.description.funderIntramural NIH HHS
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1600-0897.2009.00804.x
dc.identifier.eissn1600-0897
dc.identifier.issn1046-7408
dc.identifier.pubmedidMEDLINE:20085562
dc.identifier.urihttps://doi.org/10.1111/j.1600-0897.2009.00804.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78430
dc.identifier.wosidWOS:000274388000011
dc.information.autorucMedicina;Gómez R;S/I;80926
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final262
dc.pagina.inicio252
dc.publisherWILEY
dc.revistaAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
dc.rightsacceso restringido
dc.subjectAcute bacterial infection
dc.subjectadipokines
dc.subjectBMI
dc.subjectcytokine
dc.subjectinfection
dc.subjectinflammation
dc.subjectmaternal obesity
dc.subjectoverweight
dc.subjectpregnancy
dc.subjecturinary tract infection
dc.subjectSERUM ADIPONECTIN MULTIMERS
dc.subjectFACTOR GENE POLYMORPHISMS
dc.subjectVISFATIN CONCENTRATIONS
dc.subjectAMNIOTIC-FLUID
dc.subjectADIPOSE-TISSUE
dc.subjectGESTATIONAL-AGE
dc.subjectINSULIN-RESISTANCE
dc.subjectIMMUNE-RESPONSE
dc.subjectMESSENGER-RNA
dc.subjectLEPTIN LEVELS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMaternal Plasma Concentration of the Pro-Inflammatory Adipokine Pre-B-Cell-Enhancing Factor (PBEF)/Visfatin Is Elevated In Pregnant Patients with Acute Pyelonephritis
dc.typeartículo
dc.volumen63
sipa.codpersvinculados80926
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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