Soluble ST2: A new and promising activity marker in ulcerative colitis

Simple item page
dc.contributor.authorDiaz Jimenez, David
dc.contributor.authorNunez, Lucia E.
dc.contributor.authorBeltran, Caroll J.
dc.contributor.authorCandia, Enzo
dc.contributor.authorSuazo, Cristobal
dc.contributor.authorAlvarez Lobos, Manuel
dc.contributor.authorGonzalez, Maria Julieta
dc.contributor.authorHermoso, Marcela A.
dc.contributor.authorQuera, Rodrigo
dc.date.accessioned2024-01-10T12:08:41Z
dc.date.available2024-01-10T12:08:41Z
dc.date.issued2011
dc.description.abstractAIM: To correlate circulating soluble ST2 (sST2) levels with the severity of ulcerative colitis (UC) and serum levels of pro-inflammatory cytokines, and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.
dc.description.abstractMETHODS: We recruited 153 patients: 82 with UC, 26 with Crohn's disease (CD) and 43 disease controls [non-inflammatory bowel disease (IBD)]. Subjects were excluded if they had diagnosis of asthma, autoimmune diseases or hypertension. The serum levels of sST2 and pro-inflammatory cytokines [pg/mL; median (25th-75th)] as well as clinical features, endoscopic and histological features, were subjected to analyses. The sST2 performance for discrimination between active and inactive UC, non-IBD and healthy controls (HC) was determined with regard to sensitivity and specificity, and Spearman's rank correlation coefficient (r). To validate the method, the area under the curve (AUC) of receiver-operator characteristic (ROC) was determined (AUC, 95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.
dc.description.abstractRESULTS: The serum sST2 value was significantly higher in patients with active [235.80 (90.65-367.90) pg/mL] rather than inactive UC [33.19 (20.04-65.32) pg/mL], based on clinical, endoscopic and histopathological characteristics, as well as compared with non-IBD and HC (P < 0.001). The median level of sST2 in CD patients was 54.17 (35.02-122.0) pg/mL, significantly higher than that of the HC group only (P < 0.01). The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients. Values of sensitivity, specificity, and ability to correctly classify UC, according to activity, were 83.33%, 83.33% and 83.33%, respectively. The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92 (0.86-0.97, P < 0.0001). The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histopathological scores (r = 0.76 and r = 0.67, P < 0.0001, respectively), and with the pro-inflammatory cytokine, tumor necrosis factor-a (r = 0.69 and r = 0.61, respectively, P < 0.0001). Interestingly, we found a direct correlation between total intestinal ST2 content and serum levels of sST2, adjusted to endoscopic activity score in patients with mild (r = 0.44, P = 0.004), moderate (r = 0.59, P = 0.002) and severe disease (r = 0.82, P = 0.002). Only patients with inactive UC showed no significant correlation (r = 0.45, P = 0.267).
dc.description.abstractCONCLUSION: sST2 levels correlated with disease severity and inflammatory cytokines, are able to differentiate active from inactive UC and might have a role as a biomarker. (C) 2011 Baishideng. All rights reserved.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-05-27
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3748/wjg.v17.i17.2181
dc.identifier.issn1007-9327
dc.identifier.pubmedidMEDLINE:21633527
dc.identifier.urihttps://doi.org/10.3748/wjg.v17.i17.2181
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76417
dc.identifier.wosidWOS:000290689300004
dc.information.autorucMedicina;Alvarez M;S/I;6131
dc.issue.numero17
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final2190
dc.pagina.inicio2181
dc.publisherBAISHIDENG PUBL GRP CO LTD
dc.revistaWORLD JOURNAL OF GASTROENTEROLOGY
dc.rightsacceso abierto
dc.subjectInflammatory bowel disease
dc.subjectUlcerative colitis
dc.subjectSoluble ST2
dc.subjectBiomarkers
dc.subjectINFLAMMATORY-BOWEL-DISEASE
dc.subjectC-REACTIVE PROTEIN
dc.subjectDESTABILIZED HEART-FAILURE
dc.subjectFECAL CALPROTECTIN
dc.subjectCROHNS-DISEASE
dc.subjectBLOOD LEUKOCYTES
dc.subjectINTESTINAL INFLAMMATION
dc.subjectAIRWAY INFLAMMATION
dc.subjectCLINICAL ACTIVITY
dc.subjectACTIVITY INDEX
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSoluble ST2: A new and promising activity marker in ulcerative colitis
dc.typeartículo
dc.volumen17
sipa.codpersvinculados6131
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Soluble ST2 - A new and promising activity marker in ulcerative colitis.pdf
Size:
926.16 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas