Transient increase of brain derived neurotrophic factor mRNA expression in substantia nigra reticulata after partial lesion of the nigrostriatal dopaminergic pathway

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dc.contributor.authorAliaga, E
dc.contributor.authorCárcamo, C
dc.contributor.authorAbarca, J
dc.contributor.authorTapia-Arancibia, L
dc.contributor.authorBustos, G
dc.date.accessioned2025-01-21T01:31:18Z
dc.date.available2025-01-21T01:31:18Z
dc.date.issued2000
dc.description.abstractBy using non-isostopic in situ hybridization we have demonstrated a transient increase of BDNF mRNA in the lateral subregion of the substantia nigra pars reticulata 1 week after intrastriatal application of 6-OH-DA. These changes correlate with a partial reduction of dopamine (DA) content in the striatum but with a normal tyrosine hydroxylase immunoreactivity in substantia nigra pars compacta. Our data suggest that non-DA, BDNF expressing cells in substantia nigra pars reticulata may play a role in neuronal protection after partial lesions of the DA nigrostriatal pathway. (C) 2000 Elsevier Science B.V. All rights reserved.
dc.fuente.origenWOS
dc.identifier.issn0169-328X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97033
dc.identifier.wosidWOS:000088791000014
dc.issue.numero1-2
dc.language.isoen
dc.pagina.final155
dc.pagina.inicio150
dc.revistaMolecular brain research
dc.rightsacceso restringido
dc.subjectBDNF
dc.subjectsubstantia nigra
dc.subjectpars reticulata
dc.subject6-OH-DA
dc.subjectin situ hybridization
dc.subjectDA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTransient increase of brain derived neurotrophic factor mRNA expression in substantia nigra reticulata after partial lesion of the nigrostriatal dopaminergic pathway
dc.typeartículo
dc.volumen79
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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