Helicobacter pylori vacA s1a and s1b alleles from clinical isolates from different regions of Chile show a distinct geographic distribution

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dc.contributor.authorDiaz, M. I.
dc.contributor.authorValdivia, A.
dc.contributor.authorMartinez, P.
dc.contributor.authorPalacios, J. L.
dc.contributor.authorHarris, P.
dc.contributor.authorNovales, J.
dc.contributor.authorGarrido, E.
dc.contributor.authorValderrama, D.
dc.contributor.authorShilling, C.
dc.contributor.authorKirberg, A.
dc.contributor.authorHebel, E.
dc.contributor.authorFierro, J.
dc.contributor.authorBravo, R.
dc.contributor.authorSiegel, F.
dc.contributor.authorLeon, G.
dc.contributor.authorKlapp, G.
dc.contributor.authorVenegas, A.
dc.date.accessioned2024-01-10T12:39:19Z
dc.date.available2024-01-10T12:39:19Z
dc.date.issued2005
dc.description.abstractAIM: To establish the most common vacA alleles in Helicobacter pylori (H pylori) strains isolated from Chilean patients and its relationship with gastritis and gastroduodenal ulcers.
dc.description.abstractMETHODS: Two hundred and forty five H pylori clinical isolates were obtained from 79 biopsies from Chilean infected patients suffering gastrointestinal diseases. An average of 2-3 strains per patient was isolated and the vacA genotype was analyzed by PCR and 3% agarose electrophoresis. Some genotypes were checked by DNA sequencing.
dc.description.abstractRESULTS: The most prevalent vacA genotype in Chilean patients was s1b m1 (76%), followed by s1a m1 (21%). In contrast, the s2 m2 genotype was scarcely represented (3%). The s1b m1 genotype was found most frequently linked to gastropathies (P < 0.05) rather than ulcers. Ulcers were found more commonly in male and older patients. Curiously, patients living in cities located North and far South of Santiago, the capital and largest Chilean city, carried almost exclusively strains with the s1b m1 genotype. In contrast, patients from Santiago and cities located South of Santiago carried strains with either one or both s1a m1 and s1b m1 genotypes. Regarding the s2 m2 genotype, comparison with Genbank sequences revealed that Chilean s2 sequence was identical to those of Australian, American and Colombian strains but quite different from those of Alaska and India.
dc.description.abstractCONCLUSION: Differences in geographic distribution of the s and m vacA alleles in Chile and a relationship of s1b m1 genotype with gastritis were found. Sequence data in part support a hispanic origin for the vacA genoytype. Asymetric distribution of genotypes s1b m1 and s2 m2 remedes H Pylori strain distribution in Spain and Portugal. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.
dc.description.funderFONDECYT
dc.description.funderComision Nacional Cientifica y Tecnologica, Chile
dc.description.funderNIH
dc.description.funderNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
dc.fechaingreso.objetodigital2024-05-27
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3748/wjg.v11.i40.6366
dc.identifier.eissn2219-2840
dc.identifier.issn1007-9327
dc.identifier.pubmedidMEDLINE:16419167
dc.identifier.urihttps://doi.org/10.3748/wjg.v11.i40.6366
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77176
dc.identifier.wosidWOS:000208318000019
dc.information.autorucMedicina;Harris P;S/I;80706
dc.issue.numero40
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final6372
dc.pagina.inicio6366
dc.publisherBAISHIDENG PUBLISHING GROUP INC
dc.revistaWORLD JOURNAL OF GASTROENTEROLOGY
dc.rightsacceso abierto
dc.subjectH pylori
dc.subjectvacA alleles
dc.subjectChilean isolates
dc.subjects1
dc.subjects2
dc.subjectm1 and m2 sequences
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHelicobacter pylori vacA s1a and s1b alleles from clinical isolates from different regions of Chile show a distinct geographic distribution
dc.typeartículo
dc.volumen11
sipa.codpersvinculados80706
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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