The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific

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dc.contributor.authorBueno, Susan M.
dc.contributor.authorGonzalez, Pablo A.
dc.contributor.authorCarreno, Leandro J.
dc.contributor.authorTobar, Jaime A.
dc.contributor.authorMora, Guido C.
dc.contributor.authorPereda, Cristian J.
dc.contributor.authorSalazar Onfray, Flavio
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-01-10T12:09:21Z
dc.date.available2024-01-10T12:09:21Z
dc.date.issued2008
dc.description.abstractInfection with Salmonella enterica serovar Typhimurium (S. Typhimurium) causes a severe and lethal systemic disease in mice, characterized by poor activation of the adaptive immune response against Salmonella-derived antigens. Recently, we and others have reported that this feature relies on the ability of S. Typhimurium to survive within murine dendritic cells (DCs) and avoid the presentation of bacteria-derived antigens to T cells. In contrast, here we show that infection of murine DCs with either S. Typhi or S. Enteritidis, two serovars adapted to different hosts, leads to an efficient T-cell activation both in vitro and in vivo. Accordingly, S. Typhi and S. Enteritidis failed to replicate within murine DCs and were quickly degraded, allowing T-cell activation. In contrast, human DCs were found to be permissive for survival and proliferation of S. Typhi, but not for S. Typhimurium or S. Enteritidis. Our data suggest that Salmonella host restriction is characterized by the ability of these bacteria to survive within DCs and avoid activation of the adaptive immune response in their specific hosts.
dc.fechaingreso.objetodigital2024-05-07
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1365-2567.2008.02805.x
dc.identifier.issn0019-2805
dc.identifier.pubmedidMEDLINE:18266715
dc.identifier.urihttps://doi.org/10.1111/j.1365-2567.2008.02805.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76482
dc.identifier.wosidWOS:000257514300010
dc.information.autorucCiencias Biológicas;Bueno S;S/I;113541
dc.information.autorucCiencias Biológicas;Carreño L;S/I;120819
dc.information.autorucMedicina;González P;S/I;117422
dc.information.autorucCiencias Biológicas;Kalergis A;S/I;90610
dc.information.autorucCiencias Biológicas;Tobar J;S/I;13024
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final533
dc.pagina.inicio522
dc.publisherWILEY-BLACKWELL
dc.revistaIMMUNOLOGY
dc.rightsacceso restringido
dc.subjectdendritic cells
dc.subjecthost restriction
dc.subjectSalmonella
dc.subjectT cell
dc.subjectENTERICA SEROVAR TYPHIMURIUM
dc.subjectCOMPLETE GENOME SEQUENCE
dc.subjectIII SECRETION SYSTEM
dc.subjectADAPTIVE IMMUNITY
dc.subjectPATHOGENICITY ISLAND
dc.subjectSEROTYPE TYPHIMURIUM
dc.subjectTYPHOID-FEVER
dc.subjectIN-VITRO
dc.subjectINFECTION
dc.subjectMICE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific
dc.typeartículo
dc.volumen124
sipa.codpersvinculados113541
sipa.codpersvinculados120819
sipa.codpersvinculados117422
sipa.codpersvinculados90610
sipa.codpersvinculados13024
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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