Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus

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dc.contributor.authorCodner, Ethel
dc.contributor.authorRocha, Ana
dc.contributor.authorDeng, Liyong
dc.contributor.authorMartinez Aguayo, Alejandro
dc.contributor.authorGodoy, Claudia
dc.contributor.authorMericq, Veronica
dc.contributor.authorChung, Wendy K.
dc.date.accessioned2024-01-10T12:40:24Z
dc.date.available2024-01-10T12:40:24Z
dc.date.issued2009
dc.description.abstractBackground: Incidental hyperglycemia in children generates concern about the presence of preclinical type I diabetes mellitus (T1DM).
dc.description.abstractObjective: To genetically evaluate two corm-non forms of maturity-onset diabetes of youth (MODY), the short-term prognosis in children with mild hyperglycemia, and a positive family history of diabetes mellitus.
dc.description.abstractSubjects: Asymptomatic children and adolescents (n = 14), younger than 15 yr, with fasting hyperglycemia, a positive family history of mild non-progressive hyperglycemia, and negative pancreatic autoantibodies were studied.
dc.description.abstractPatients and methods: Glucokinase gene (GCK) and hepatocyte nuclear factor I alpha gene (HNF1A) causing two common forms of MODY were sequenced. The clinical outcome was evaluated after a follow-up period of 2.8 +/- 1.3 yr.
dc.description.abstractResults: GCK mutations were present in seven children. The confirmation of this diagnosis allowed discontinuation of insulin in two families and oral medications in three families. Mutations of HNF1A were not detected in any of the families. During the follow-up period, all the GCK mutation carrier children remained asymptomatic without medication and the last hemoglobin Ale levels were 6.4 +/- 0.7%. In the GCK-negative children (n = 7), one developed T1DM, corresponding to 7.2% of the total group. Mild fasting hyperglycemia persisted during follow-up ill four GCK-negative children and normalized in the remaining two.
dc.description.abstractConclusions: The presence of mild persistent hyperglycemia in any patient without autoantibodies should lead to genetic analysis of GCK, particularly if there is a positive family history. Furthermore, those without GCK mutations should be followed with repeat autoantibody testing, and other genetic types of diabetes should be considered if hyperglycemia worsens.
dc.description.funderNIDDK
dc.description.funderNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
dc.fechaingreso.objetodigital2024-05-09
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1399-5448.2009.00499.x
dc.identifier.eissn1399-5448
dc.identifier.issn1399-543X
dc.identifier.pubmedidMEDLINE:19309449
dc.identifier.urihttps://doi.org/10.1111/j.1399-5448.2009.00499.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77305
dc.identifier.wosidWOS:000269984100005
dc.information.autorucMedicina;Martínez-Aguayo A;S/I;1003862
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final388
dc.pagina.inicio382
dc.publisherWILEY
dc.revistaPEDIATRIC DIABETES
dc.rightsacceso restringido
dc.subjectDM
dc.subjectgenetics
dc.subjectglucokinase
dc.subjecthyperglycemia
dc.subjectincidental hyperglycemia
dc.subjectMODY
dc.subjectprognosis
dc.subjectINCIDENTAL HYPERGLYCEMIA
dc.subjectGLUCOSE
dc.subjectMODY
dc.subjectDIAGNOSIS
dc.subjectGENES
dc.subjectPREVALENCE
dc.subjectGUIDELINES
dc.subjectYOUNG
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus
dc.typeartículo
dc.volumen10
sipa.codpersvinculados1003862
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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